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. 2024;77(2):320-325.
doi: 10.5173/ceju.2023.261R. Epub 2024 Apr 11.

Is urethral stricture really so often idiopathic? Exploring the etiology of urethral strictures in males undergoing urethroplasty: a multicenter retrospective cohort study

Łukasz Białek  1 , Marta Rydzińska  1 , Mikołaj Frankiewicz  2 , Adam Kałużny  2 , Jakub Dobruch  1 , Marcin Matuszewski  2 , Michał Skrzypczyk  1
Affiliations

Is urethral stricture really so often idiopathic? Exploring the etiology of urethral strictures in males undergoing urethroplasty: a multicenter retrospective cohort study

Łukasz Białek et al. Cent European J Urol. 2024.

Abstract

Introduction: The aim of this study was to retrospectively evaluate the etiology of urethral stricture disease (USD) in a large series of patients undergoing urethroplasty.

Material and methods: The multicenter retrospective cohort study was conducted at two reconstructive urology referral centers in years 2015-2022. Prior to the surgical intervention, all patients underwent diagnostic procedures including retrograde urethrography and voiding cystourethrography. We collected comprehensive demographic and medical data including the length and location of the stricture. We paid particular attention to identifying the underlying causes of USD in the medical records.

Results: The study included 949 patients meeting criteria, with a mean age of 53. The primary cause of USD was identified as iatrogenic (404 cases, 42.6%), followed by trauma (210, 22.1%), previous hypospadias repair (122, 12.9%), lichen sclerosus (32, 3.4%), and infections (12, 1.3%). Notably, 169 patients (17.8%) did not have a discernible cause for their USD and were thus classified as idiopathic. Furthermore, it was observed that 66% of idiopathic USD cases were localized in the bulbar urethra. The etiology of USD varied significantly based on its localization (p <0.01). The mean stricture length differed among different causes, with the longest in patients with USD due to lichen sclerosus (41 mm), followed by previous hypospadias repair (35 mm), and iatrogenic causes (29 mm), p <0.001.

Conclusions: Careful medical history-taking can identify the etiology of urethral stricture in over 80% of patients undergoing urethroplasty. The etiology of the USD impacts its location and length and thus can affect surgical treatment strategy and outcomes.

Keywords: etiology; urethral stricture; urethroplasty.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
The incidence of localisation of urethral stricture by its etiology.
See this image and copyright information in PMC

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References

    1. Santucci RA, Joyce GF, Wise M. Male urethral stricture disease. J Urol. 2007; 177: 1667-1674. - PubMed
    1. Lumen N, Campos-Juanatey F, Greenwell T, et al. . European Association of Urology Guidelines on Urethral Stricture Disease (Part 1): Management of Male Urethral Stricture Disease. Eur Urol. 2021; 80: 190-200. - PubMed
    1. Roehrborn CG, McConnell JD. Analysis of Factors Contributing to Success or Failure of 1-Stage Urethroplasty for Urethral Stricture Disease. Journal of Urology. 1994; 151: 869-874. - PubMed
    1. Verla W, Oosterlinck W, Spinoit AF, Waterloos M. A Comprehensive Review Emphasizing Anatomy, Etiology, Diagnosis, and Treatment of Male Urethral Stricture Disease. BioMed Res Int. 2019; 2019: 1-20. - PMC - PubMed
    1. Stein DM, Thum DJ, Barbagli G, et al. . A geographic analysis of male urethral stricture aetiology and location: Male urethral stricture aetiology and location. BJU Int. 2013; 112: 830-834. - PubMed

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