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Review
. 2024;77(2):339-343.
doi: 10.5173/ceju.2024.17. Epub 2024 May 20.

Nitroxoline: treatment and prevention of urinary tract infections from the urologist's perspective

Wojciech Krajewski  1 , Jan Łaszkiewicz  2 , Wojciech Tomczak  2 , Łukasz Nowak  1 , Joanna Chorbińska  1 , Aleksandra Sójka  2 , Bartosz Małkiewicz  1 , Tomasz Szydełko  2
Affiliations
Review

Nitroxoline: treatment and prevention of urinary tract infections from the urologist's perspective

Wojciech Krajewski et al. Cent European J Urol. 2024.

Abstract

Introduction: Nitroxoline is an old antimicrobial agent with a broad spectrum of pharmacological applications and a unique mechanism of action. However, its use in the treatment and prevention of urinary tract infections (UTIs) has not been popular in the recent past. Recently, nitroxoline is gaining interest, due to frequent drug-resistance in uropathogens. Unfortunately, there are few modern clinical trials assessing this antibiotic. Also, older researchers often do not meet current scientific standards. This review seeks to provide a comprehensive overview of nitroxoline as a viable option in treating uncomplicated lower UTIs.

Material and methods: A comprehensive literature search regarding the use of nitroxoline in UTIs was conducted using Pubmed, Cochrane Library and Embase databases. A cross-reference search was also performed. Case reports, editorials and non-peer-reviewed literature were excluded from further analysis. As a result, 21 publications were included in this review.

Results: The available literature on nitroxoline's mechanism of action, pharmacokinetics, minimum inhibitory concentrations, in vitro activity and resistance rates strongly suggests that nitroxoline is a potent broad-spectrum antimicrobial agent. Moreover, clinical efficacy of the drug was analyzed - 2 articles proved high eradication rates in women with uncomplicated lower UTIs and 1 reported unsuccessful treatment in geriatric patients with lower complicated and uncomplicated UTIs. Finally, the present data on adverse effects indicate that nitroxoline is well-tolerated.

Conclusions: Nitroxoline is an obscure, yet potentially effective and safe antimicrobial agent in uncomplicated lower UTIs. Unfortunately, it is available only in a few countries. Nonetheless, nitroxoline can be useful in urological practice.

Keywords: 5-nitro-8-hydroxyquinoline; Nitroxoline; cystitis; urinary tract infection.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Flow diagram of the study selection process.
See this image and copyright information in PMC

References

    1. Repac Antić D, Parčina M, Gobin I, Petković Didović M. Chelation in Antibacterial Drugs: From Nitroxoline to Cefiderocol and Beyond. Antibiotics (Basel). 2022; 11: 1105. - PMC - PubMed
    1. European Committee on Antimicrobial Susceptibility Testing . Nitroxoline: Rationale for the clinical breakpoints, version 1.0 2016. Available from: http://www.eucast.org.
    1. Kranz J, Schmidt S, Lebert C, et al. The 2017 Update of the German Clinical Guideline on Epidemiology, Diagnostics, Therapy, Prevention, and Management of Uncomplicated Urinary Tract Infections in Adult Patients: Part 1. Urol Int. 2018; 100: 263-270. - PubMed
    1. Naber KG, Niggemann H, Stein G. Review of the literature and individual patients' data meta-analysis on efficacy and tolerance of nitroxoline in the treatment of uncomplicated urinary tract infections. BMC Infect Dis. 2014; 14: 628. - PMC - PubMed
    1. Latrache H, Bourlioux P, Karroua M, Zahir H, Hakkou A. Effects of subinhibitory concentrations of nitroxoline on the surface properties of Escherichia coli. Folia Microbiol (Praha). 2000; 45: 485-490. - PubMed

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