BRASH (Bradycardia, Renal Failure, Atrioventricular Nodal Blockade, Shock, and Hyperkalemia) Syndrome: A Frequently Underrecognized Condition Often Confused With Simple Hyperkalemia
- PMID: 39347275
- PMCID: PMC11438024
- DOI: 10.7759/cureus.68106
BRASH (Bradycardia, Renal Failure, Atrioventricular Nodal Blockade, Shock, and Hyperkalemia) Syndrome: A Frequently Underrecognized Condition Often Confused With Simple Hyperkalemia
Abstract
BRASH syndrome, defined by bradycardia, renal failure, atrioventricular nodal blockade, shock, and hyperkalemia, is a relatively new and often underrecognized condition. In this article, we present a case of an elderly female who developed an episode of syncope. She was found to have refractory shock and bradycardia in the emergency department. Laboratory results and other findings led to the diagnosis of a BRASH syndrome, which was refractory to medical therapy alone, requiring transvenous pacing, hemodialysis, and vasopressor support.
Keywords: acute renal failure and hemodialysis in icu; av nodal blockers; bradycardia; brash syndrome; cardiology; hyperkalemia.
Copyright © 2024, Singh et al.
Conflict of interest statement
Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.
Figures
Similar articles
-
Bradycardia, Renal Failure, Atrioventricular Nodal Blockade, Shock and Hyperkalemia (BRASH) Syndrome: A Clinical Case Study.Cureus. 2023 Feb 9;15(2):e34803. doi: 10.7759/cureus.34803. eCollection 2023 Feb. Cureus. 2023. PMID: 36788997 Free PMC article.
-
Bradycardia, Renal Failure, Atrioventricular (AV) Nodal Blockers, Shock, and Hyperkalemia (BRASH) Syndrome: A Confounder in the Clinical Practice.Cureus. 2024 Oct 31;16(10):e72793. doi: 10.7759/cureus.72793. eCollection 2024 Oct. Cureus. 2024. PMID: 39618623 Free PMC article.
-
When a Cure Becomes a Curse: The Complex Clinical Scenario Involving Amiodarone Therapy and BRASH (Bradycardia, Renal failure, Atrioventricular Nodal Blockade, Shock, and Hyperkalemia) Syndrome.Cureus. 2023 May 6;15(5):e38622. doi: 10.7759/cureus.38622. eCollection 2023 May. Cureus. 2023. PMID: 37284357 Free PMC article.
-
Clinical characteristics of BRASH syndrome: Systematic scoping review.Eur J Intern Med. 2022 Sep;103:57-61. doi: 10.1016/j.ejim.2022.06.002. Epub 2022 Jun 5. Eur J Intern Med. 2022. PMID: 35676108
-
From Salvador Dali and Von Gogh to BRASH: a case-based systematic literature review of digoxin induced BRASH syndrome.Future Cardiol. 2025 Mar;21(4):211-216. doi: 10.1080/14796678.2025.2466995. Epub 2025 Feb 15. Future Cardiol. 2025. PMID: 39953848
Cited by
-
The Interplay Between Hypocalcemia and Atrioventricular Nodal Blocking Agents in Inducing a Bradycardia, Renal Failure, Atrioventricular Nodal Blockade, Shock, and Hyperkalemia (BRASH)-Like Phenomenon With Serial Serum Drug Concentrations.Cureus. 2025 Feb 12;17(2):e78925. doi: 10.7759/cureus.78925. eCollection 2025 Feb. Cureus. 2025. PMID: 40091947 Free PMC article.
References
-
- BRASH syndrome: bradycardia, renal failure, AV blockade, shock, and hyperkalemia. Farkas JD, Long B, Koyfman A, Menson K. J Emerg Med. 2020;59:216–223. - PubMed
-
- BRASH syndrome - fact or fiction? A first analysis of the prevalence and relevance of a newly described syndrome. Ravioli S, Woitok BK, Lindner G. Eur J Emerg Med. 2021;28:153–155. - PubMed
Publication types
LinkOut - more resources
Full Text Sources