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. 2024 Nov 1;25(11):775-780.
doi: 10.2459/JCM.0000000000001665. Epub 2024 Sep 13.

Prognostic significance of electrophysiological study in drug-induced type-1 Brugada syndrome: a brief systematic review

Giuseppe Mascia  1 , Josep Brugada  2   3   4   5   6 , Luca Barca  7 , Stefano Benenati  7 , Roberta Della Bona  1 , Antonio Scarà  8 , Vincenzo Russo  9 , Elena Arbelo  3   4   5   6 , Paolo Di Donna  1 , Italo Porto  1   7
Affiliations

Prognostic significance of electrophysiological study in drug-induced type-1 Brugada syndrome: a brief systematic review

Giuseppe Mascia et al. J Cardiovasc Med (Hagerstown). .

Abstract

Background: Risk stratification in drug-induced type-1 Brugada syndrome (BrS) patients is challenging. The role of electrophysiological study (EPS) is debated as the majority of drug-induced type-1 BrS patients would not be studied according to the latest recommendations.

Methods: A complete systematic literature search was performed to gauge the EPS role in this population. Three subgroups were defined: positive-EPS group, negative-EPS group, no-EPS group.

Results: Among 1318 drug-induced type-1 BrS patients, no significant difference in the incidence rate of arrhythmic events was observed between groups (I2 = 45%, P for subgroup difference = 0.10) during a mean follow-up of 5.1 years, also considering symptomatic status.

Conclusion: In long-term follow-up of drug-induced type-1 BrS patients, EPS does not seem to aid prognostic stratification.

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References

    1. Brugada J, Campuzano O, Arbelo E, Sarquella-Brugada G, Brugada R. Present status of Brugada syndrome: JACC state-of-the-art review. J Am Coll Cardiol 2018; 72:1046–1059.
    1. Mascia G, Bona RD, Ameri P, et al. Brugada syndrome and syncope: a practical approach for diagnosis and treatment. Europace 2021; 23:996–1002.
    1. Probst V, Veltmann C, Eckardt L, et al. Long-term prognosis of patients diagnosed with Brugada syndrome: results from the FINGER Brugada Syndrome Registry. Circulation 2010; 121:635–643.
    1. Russo V, Pafundi PC, Caturano A, et al. Electrophysiological study prognostic value and long-term outcome in drug-induced type 1 Brugada Syndrome: the IBRYD Study. JACC Clin Electrophysiol 2021; 7:1264–1273.
    1. Takagi M, Sekiguchi Y, Yokoyama Y, Aihara N, Hiraoka M, Aonuma K. Japan Idiopathic Ventricular Fibrillation Study (J-IVFS) Investigators. The prognostic impact of single extra-stimulus on programmed ventricular stimulation in Brugada patients without previous cardiac arrest: multicentre study in Japan. Europace 2018; 20:1194–1200.

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