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Review
. 2024 Sep 30;51(1):1027.
doi: 10.1007/s11033-024-09965-w.

The prognostic and therapeutic potential of vimentin in colorectal cancer

Zahra Kalaei  1 , Ali Akbar Shekarchi  2 , Mohammad Hojjat-Farsangi  3 , Pooya Jalali  4 , Farhad Jadidi-Niaragh  5   6   7
Affiliations
Review

The prognostic and therapeutic potential of vimentin in colorectal cancer

Zahra Kalaei et al. Mol Biol Rep. .

Abstract

Several cells and molecules in the tumor microenvironment have been introduced as effective factors in the prognosis and progression of colorectal cancer. As a key element of the intermediate filament family, vimentin is expressed by mesenchymal cells in a ubiquitous manner and contributes significantly to cellular integrity and stress resistance in colorectal cancer. Recent studies have shown that alterations in the expression patterns of intermediate filaments are significantly related to cancer progression, especially in phenotypes associated with cellular migration and invasion. In addition to its multiple biological roles, vimentin also has a substantial function in mediating the epithelial-mesenchymal transition. Therefore, evaluating vimentin as an effective factor involved in the prognosis of colorectal cancer and targeting it as a novel approach to cancer therapy have become one of the main goals of many researchers worldwide. In this article, we will review the various biological functions of vimentin, as well as its relationship with colorectal cancer with the aim of providing novel insights into its clinical importance in the prognosis and treatment of colorectal cancer.

Keywords: Colorectal cancer; Prognostic marker; Therapeutic target; Vimentin.

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