Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Sep 30;51(1):1027.
doi: 10.1007/s11033-024-09965-w.

The prognostic and therapeutic potential of vimentin in colorectal cancer

Zahra Kalaei  1 , Ali Akbar Shekarchi  2 , Mohammad Hojjat-Farsangi  3 , Pooya Jalali  4 , Farhad Jadidi-Niaragh  5   6   7
Affiliations
Review

The prognostic and therapeutic potential of vimentin in colorectal cancer

Zahra Kalaei et al. Mol Biol Rep. .

Abstract

Several cells and molecules in the tumor microenvironment have been introduced as effective factors in the prognosis and progression of colorectal cancer. As a key element of the intermediate filament family, vimentin is expressed by mesenchymal cells in a ubiquitous manner and contributes significantly to cellular integrity and stress resistance in colorectal cancer. Recent studies have shown that alterations in the expression patterns of intermediate filaments are significantly related to cancer progression, especially in phenotypes associated with cellular migration and invasion. In addition to its multiple biological roles, vimentin also has a substantial function in mediating the epithelial-mesenchymal transition. Therefore, evaluating vimentin as an effective factor involved in the prognosis of colorectal cancer and targeting it as a novel approach to cancer therapy have become one of the main goals of many researchers worldwide. In this article, we will review the various biological functions of vimentin, as well as its relationship with colorectal cancer with the aim of providing novel insights into its clinical importance in the prognosis and treatment of colorectal cancer.

Keywords: Colorectal cancer; Prognostic marker; Therapeutic target; Vimentin.

PubMed Disclaimer

References

    1. Siegel RL, Giaquinto AN, Jemal A (2024) Cancer statistics, 2024. CA Cancer J Clin 74(1):12–49
    1. Bray F et al (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68(6):394–424
    1. Naxerova K et al (2017) Origins of lymphatic and distant metastases in human colorectal cancer. Science 357(6346):55–60
    1. Bajpai P et al (2024) Combination of dual JAK/HDAC inhibitor with regorafenib synergistically reduces tumor growth, metastasis, and regorafenib-induced toxicity in colorectal cancer. J Exp Clin Cancer Res 43(1):192
    1. Lin YM et al (2021) Image-guided ablation for colorectal liver metastasis: principles, current evidence, and the path Forward. Cancers (Basel), 13(16)

LinkOut - more resources