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. 2024 Sep 30;14(1):46.
doi: 10.1186/s12348-024-00433-x.

Bilateral purtscher-like retinopathy associated with DRESS syndrome: a case report

Langxuan Yuan  1 , Yuchen Li  1 , Hanze Zhang  1 , Yucen Hou  1 , Qianyan Kang  2 , Jianqin Lei  3
Affiliations

Bilateral purtscher-like retinopathy associated with DRESS syndrome: a case report

Langxuan Yuan et al. J Ophthalmic Inflamm Infect. .

Abstract

Background: To report a case of Bilateral Purtscher-like retinopathy associated with DRESS syndrome managed with ocular and systemic treatments.

Case presentation: A 29-year-old healthy female developed multi-organ (cutaneous, hematologic, renal and hepatic) disfunction and profound vision loss 1 month after Human papillomavirus vaccine injection. At the first presentation, her visual acuity was counting fingers in both eyes. Fundus exam showed remarkable cotton-wool spots, retinal hemorrhages and macular edema. She was diagnosed DRESS syndrome and Purtscher-like retinopathy and treated with intravitreal injection of ranibizumab, systemic steroids anticoagulants, and plasma exchange. The patient finally recovered from this life-threatening condition but left with permanent visual damage.

Conclusion: Purtscher-like retinopathy could be complicated by DRESS syndrome which is usually considered a type IV hypersensitivity reaction.

Keywords: DRESS syndrome; Delayed hypersensitivity reaction; Inflammatory storm; Purtscher-like retinopathy.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
First Presentation of Bilateral Purtscher-Like Retinopathy in a 29-Year-Old Female. A: A photo of the patient’s skin. B: Bilateral fundus photographs and OCT
Fig. 2
Fig. 2
One-Month Follow-up of Bilateral Purtscher-Like Retinopathy in a 29-Year-Old Female
See this image and copyright information in PMC

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