Half-Dose Tenecteplase or Primary Percutaneous Coronary Intervention in Older Patients With ST-Elevation Myocardial Infarction: STREAM-2 1-Year Mortality Follow-Up

Peter R Sinnaeve^{1

2}, Robert C Welsh³, Alexandra Arias Mendoza⁴, Arsen D Ristić⁵, Oleg V Averkov⁶, Yves Lambert⁷, José F Kerr Saraiva⁸, Pablo Sepulveda⁹, Fernando Rosell-Ortiz¹⁰, John K French¹¹, Ljilja B Musić¹², Katleen Vandenberghe¹, Kris Bogaerts^{13

14}, Thierry Danays¹⁵, Kevin R Bainey³, Paul W Armstrong³, Frans Van de Werf²; STREAM-2 Investigators

Affiliations

¹ Department of Cardiovascular Medicine, University Hospitals Leuven, Belgium (P.R.S., K.V.).
² Department of Cardiovascular Sciences (P.R.S., F.V.d.W.), KU Leuven, Belgium.
³ Canadian Virtual Coordinating Center for Global Collaborative Cardiovascular Research, University of Alberta, Edmonton, Canada (R.C.W., K.R.B., P.W.A.).
⁴ Coronary Care Unit, National Institute of Cardiology, Mexico City (A.A.M.).
⁵ Department of Cardiology, University Clinical Center of Serbia, University of Belgrade, Serbia (A.D.R.).
⁶ Pirogov Russian National Research Medical University and City Clinical Hospital #15, Moscow, Russian Federation (O.V.A.).
⁷ Centre Hospitalier de Versailles, Service d'Aide médicale urgente 78 and Mobile Intensive Care Unit, France (Y.L.).
⁸ Cardiology Discipline, Pontifical Catholic University of Campinas School of Medicine, Brazil (J.F.K.S.).
⁹ Pontifica Universidad Católica de Chile, Santiago (P.S.).
¹⁰ Servicio de Urgencias y Emergencias 061 de La Rioja, Spain (F.R-O.).
¹¹ Department of Cardiology, Liverpool Hospital, Sydney, New South Wales, Australia (J.K.F.).
¹² University Clinical Center of Montenegro, University of Podgorica, Medical Faculty (L.B.M.).
¹³ Interuniversity Institute for Biostatistics and Statistical Bioinformatics (K.B.), KU Leuven, Belgium.
¹⁴ University Hasselt, Belgium (K.B.).
¹⁵ TDC, Aix en Provence, France (T.D.).

PMID: 39348454
DOI: 10.1161/CIRCULATIONAHA.124.070347

Half-Dose Tenecteplase or Primary Percutaneous Coronary Intervention in Older Patients With ST-Elevation Myocardial Infarction: STREAM-2 1-Year Mortality Follow-Up

Peter R Sinnaeve et al. Circulation. 2024 Oct.

. 2024 Oct;150(14):1151-1153.

doi: 10.1161/CIRCULATIONAHA.124.070347. Epub 2024 Sep 30.

Authors

Affiliations

¹ Department of Cardiovascular Medicine, University Hospitals Leuven, Belgium (P.R.S., K.V.).
² Department of Cardiovascular Sciences (P.R.S., F.V.d.W.), KU Leuven, Belgium.
³ Canadian Virtual Coordinating Center for Global Collaborative Cardiovascular Research, University of Alberta, Edmonton, Canada (R.C.W., K.R.B., P.W.A.).
⁴ Coronary Care Unit, National Institute of Cardiology, Mexico City (A.A.M.).
⁵ Department of Cardiology, University Clinical Center of Serbia, University of Belgrade, Serbia (A.D.R.).
⁶ Pirogov Russian National Research Medical University and City Clinical Hospital #15, Moscow, Russian Federation (O.V.A.).
⁷ Centre Hospitalier de Versailles, Service d'Aide médicale urgente 78 and Mobile Intensive Care Unit, France (Y.L.).
⁸ Cardiology Discipline, Pontifical Catholic University of Campinas School of Medicine, Brazil (J.F.K.S.).
⁹ Pontifica Universidad Católica de Chile, Santiago (P.S.).
¹⁰ Servicio de Urgencias y Emergencias 061 de La Rioja, Spain (F.R-O.).
¹¹ Department of Cardiology, Liverpool Hospital, Sydney, New South Wales, Australia (J.K.F.).
¹² University Clinical Center of Montenegro, University of Podgorica, Medical Faculty (L.B.M.).
¹³ Interuniversity Institute for Biostatistics and Statistical Bioinformatics (K.B.), KU Leuven, Belgium.
¹⁴ University Hasselt, Belgium (K.B.).
¹⁵ TDC, Aix en Provence, France (T.D.).

PMID: 39348454
DOI: 10.1161/CIRCULATIONAHA.124.070347

No abstract available

Keywords: ST elevation myocardial infarction; percutaneous coronary intervention; reperfusion; tenecteplase.

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Conflict of interest statement

Dr Sinnaeve reports consulting fees to his institution (KU Leuven). Dr Welsh reports personal fees and travel fees from Boehringer Ingelheim. Dr Van de Werf reports institutional grants from Boehringer Ingelheim. Dr Ristić reports grants from Boehringer-Ingelheim and Novartis and travel fees from Astra Zeneca and Pfizer. Dr Arias-Mendoza reports grants from Merck and Novo Nordisk and personal fees from Novartis, Roche, Bayer, Boehringer Ingelheim, and Asofarma. Dr Saraiva received personal fees from Boehringer Ingelheim, Astra Zeneca, Novo Nordisk, Lily, Janssen, Daichii Sankyo, Bayer, Novartis, Nova Quimica Brazil, and Albert Einstein Academic Research Organization Brazil. Dr Musić reports a grant from Boehringer Ingelheim and travel fees from Astra Zeneca and Pfizer. Dr Westerhout reports consulting fees from Bayer Canada. Dr Pagès is a senior medical advisor of Boehringer Ingelheim. Dr Danays reports consulting fees from Boehringer-Ingelheim. Dr Bainey reports personal fees from Bayer, Astra Zeneca, Boehringer Ingelheim, and Heritage Life Sciences (HLS) Therapeutics. Dr Armstrong reports institutional and personal grants from Merck, Bayer, Commonwealth Serum Laboratories (CSL) Limited, Eli Lilly, and Boehringer Ingelheim and personal fees from Merck, Boehringer Ingelheim, Bayer, and Novo Nordisk. All other authors report no disclosures.

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Half-Dose Tenecteplase or Primary Percutaneous Coronary Intervention in Older Patients With ST-Elevation Myocardial Infarction: STREAM-2 1-Year Mortality Follow-Up

Affiliations

Half-Dose Tenecteplase or Primary Percutaneous Coronary Intervention in Older Patients With ST-Elevation Myocardial Infarction: STREAM-2 1-Year Mortality Follow-Up

Authors

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Conflict of interest statement

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