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Review
. 2025 Jan;65(1):169-189.
doi: 10.1146/annurev-pharmtox-031124-101146. Epub 2024 Dec 17.

Evolving Approaches for Pharmacological Therapy of Obesity

Ariana M Chao  1 , Simeon Taylor  2 , Molly Moore  3 , Anastassia Amaro  4 , Thomas A Wadden  3
Affiliations
Review

Evolving Approaches for Pharmacological Therapy of Obesity

Ariana M Chao et al. Annu Rev Pharmacol Toxicol. 2025 Jan.

Abstract

Obesity is a global health concern. Progress in understanding the physiology of obesity and weight reduction has provided new drug targets. Development and testing of new antiobesity medications (AOMs) has the potential to quickly expand options for treatment. In this review, we briefly summarize the physiology of obesity and weight reduction, as well as medications currently approved for weight management. We highlight the increasing use of incretin and nutrient-stimulated hormone-based therapies. We conclude with an overview of AOMs progressing through the pipeline and discuss their implications for the rapidly evolving field of obesity management.

Keywords: GLP-1RA; antiobesity medications; drugs; medications; obesity; weight.

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