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Comment
. 2024 Oct 8;121(41):e2416357121.
doi: 10.1073/pnas.2416357121. Epub 2024 Sep 30.

Make it or break it: Protein homeostasis in the synaptonemal complex

Lisa E Kursel  1 , Ofer Rog  1
Affiliations
Comment

Make it or break it: Protein homeostasis in the synaptonemal complex

Lisa E Kursel et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

Competing interests statement:The authors declare no competing interest.

Figures

Fig. 1.
Fig. 1.
Cartoons depicting the synaptonemal complex (axes, salmon; central region [CR], green; chromosomes [DNA], blue) in wild-type flies (A) and upon usp7 knockdown (B). The right side of (A) and (B) depicts a potential mechanism by which Usp7 regulates synaptonemal complex components. usp7 knockdown could lead to increased degradation of synaptonemal complex proteins, resulting in an unbalanced deubiquitinase and ubiquitin ligase activity. Lower levels of synaptonemal complex components would result in an inability to maintain a fully assembled synaptonemal complex. (C) Fluorescent images of the fly synaptonemal complex (Left) and a polycomplex (Right). The cartoon depicts antibodies that label regions near the axes (green), which form parallel tracks ~120 nm apart, and the center of the synaptonemal complex (magenta). Polycomplexes resemble stacked synaptonemal complexes, resulting in alternating green and magenta threads with a periodicity similar to the width of the synaptonemal complex assembled on chromosomes. (Scale bar, 0.2 µm.) Images adapted from ref. , which is licensed under CC BY 4.0.
See this image and copyright information in PMC

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References

    1. Zickler D., Kleckner N., Meiosis: Dances between homologs. Annu. Rev. Genet. 57, 1–63 (2023), 10.1146/annurev-genet-061323-044915. - DOI - PubMed
    1. Lake C. M., et al. , The deubiquitinase Usp7 in Drosophila melanogaster is required for synaptonemal complex maintenance. Proc. Natl. Acad. Sci. U.S.A. 121, e2409346121 (2024). - PMC - PubMed
    1. Moses M. J., Chromosomal structures in crayfish spermatocytes. J. Biophys. Biochem. Cytol. 2, 215–218 (1956). - PMC - PubMed
    1. Carpenter A. T., Electron microscopy of meiosis in Drosophila melanogaster females: II. The recombination nodule–A recombination-associated structure at pachytene? Proc. Natl. Acad. Sci. U.S.A. 72, 3186–3189 (1975). - PMC - PubMed
    1. Hughes S. E., et al. , The E3 ubiquitin ligase Sina regulates the assembly and disassembly of the synaptonemal complex in Drosophila females. PLoS Genet. 15, e1008161 (2019). - PMC - PubMed

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