Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Aug 28;6(11):100897.
doi: 10.1016/j.xkme.2024.100897. eCollection 2024 Nov.

Alzheimer Disease-Related Biomarkers in Patients on Maintenance Hemodialysis

Arjun V Masurkar  1   2 , Nisha Bansal  3 , David K Prince  3 , Wolfgang C Winkelmayer  4 , Daniela F Ortiz  5 , Gianna Ramos  5 , Qandeel Soomro  5 , Alok Vedvyas  1   2 , Ricardo S Osorio  2   6 , Mark A Bernard  1   2 , Ludovic Debure  1   2 , Wajiha Ahmed  1   2 , Allal Boutajangout  1   2 , Thomas Wisniewski  1   2   6   7 , David M Charytan  5
Affiliations

Alzheimer Disease-Related Biomarkers in Patients on Maintenance Hemodialysis

Arjun V Masurkar et al. Kidney Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
(A-D) Biomarkers in hemodialysis (HD) patient serum compared with those in the plasma from controls with normal cognition (NL) or mild cognitive impairment (MCI). (A) Phosphorylated tau181 (p-tau181) (n = 71 NL, 38 MCI, and 37 HD). (B) Neurofilament light chain (NfL: n = 162 NL, 41 MCI, and 32 HD). (C) Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1: n = 159 NL, 40 MCI, and 32 HD). (D) Glial fibrillary acidic protein (GFAP: n = 162 NL, 41 MCI, and 32 HD); ∗P < 0.05, ∗∗∗∗P < 0.0001. (E-H) Trends in biomarker concentration based on dialysis vintage (months on HD): reduction in plasma (E) amyloid β-42/40 (Aβ42/40) ratio (n = 36) and increase in (F) p-tau181/tau ratio (n = 33), (G) NfL (n = 32), and (H) GFAP (n = 32).
See this image and copyright information in PMC

References

    1. Kuo Y.T., Li C.Y., Sung J.M., et al. Risk of dementia in patients with end-stage renal disease under maintenance dialysis-a nationwide population-based study with consideration of competing risk of mortality. Alzheimers Res Ther. 2019;11(1):31. - PMC - PubMed
    1. Post J.B., Jegede A.B., Morin K., Spungen A.M., Langhoff E., Sano M. Cognitive profile of chronic kidney disease and hemodialysis patients without dementia. Nephron Clin Pract. 2010;116(3):c247–c255. - PMC - PubMed
    1. Drew D.A., Bhadelia R., Tighiouart H., et al. Anatomic brain disease in hemodialysis patients: a cross-sectional study. Am J Kidney Dis. 2013;61(2):271–278. - PMC - PubMed
    1. Pi H.C., Xu Y.F., Xu R., et al. Cognitive impairment and structural neuroimaging abnormalities among patients with chronic kidney disease. Kidney Blood Press Res. 2016;41(6):986–996. - PubMed
    1. O'Connell G.C., Alder M.L., Webel A.R., Moore S.M. Neuro biomarker levels measured with high-sensitivity digital ELISA differ between serum and plasma. Bioanalysis. 2019;11(22):2087–2094. - PMC - PubMed