Pneumonia Induced Rise in Glucagon Promotes Endothelial Damage and Thrombogenicity

Pegah Ramezani Rad^{1

2}, Vanasa Nageswaran^{1

2

3

4

5}, Lisa Peters^{2

6

7}, Leander Reinshagen^{1

2

5}, Johann Roessler^{1

2

5}, Szandor Simmons^{2

7}, Erik Asmus^{1

7}, Corey Wittig^{2

8

9}, Markus C Brack¹⁰, Geraldine Nouailles¹⁰, Emiel P C van der Vorst^{11

12

13

14}, Sanne L Maas^{11

12}, Kristina Sonnenschein^{15

16}, Barbara J H Verhaar^{17

18}, Robert Szulcek^{1

2

8

9}, Martin Witzenrath^{10

9}, Ulf Landmesser^{1

2

3}, Wolfgang M Kuebler^{2

7

9

19

20}, Arash Haghikia^{1

2

3

5}

Affiliations

¹ Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Berlin, Germany (P.R.R., V.N., L.R., J.R., E.A., R.S., U.L., A.H.).
² German Center for Cardiovascular Research, Berlin, Germany (P.R.R., V.N., L.P., L.R., J.R., S.S., C.W., R.S., U.L., W.M.K., A.H.).
³ Friede Springer-Cardiovascular Prevention Center at Charité, Charité-Universitätsmedizin Berlin, Germany (V.N., U.L., A.H.).
⁴ Institute of Chemistry and Biochemistry (V.N.), Freie Universität Berlin, Germany.
⁵ Department of Cardiology, University Hospital St Josef-Hospital Bochum, Ruhr University Bochum, Germany (V.N., L.R., J.R., A.H.).
⁶ Institute of Biology (L.P.), Freie Universität Berlin, Germany.
⁷ Institute of Physiology (L.P., S.S., E.A., W.M.K.), Charité-Universitätsmedizin Berlin, corporate member of the Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany.
⁸ Laboratory of In Vitro Modeling Systems of Pulmonary and Thrombotic Diseases, Institute of Physiology (C.W., R.S.), Charité-Universitätsmedizin Berlin, corporate member of the Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany.
⁹ German Center for Lung Research (DZL), Germany (C.W., R.S., M.W., W.M.K.).
¹⁰ Department of Infectious Diseases, Respiratory Medicine and Critical Care (M.C.B., G.N., M.W.), Charité-Universitätsmedizin Berlin, corporate member of the Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany.
¹¹ Institute for Molecular Cardiovascular Research (E.P.C.v.d.V., S.L.M.), RWTH Aachen University, Germany.
¹² Aachen-Maastricht Institute for CardioRenal Disease (E.P.C.v.d.V., S.L.M.), RWTH Aachen University, Germany.
¹³ Interdisciplinary Center for Clinical Research (E.P.C.v.d.V.), RWTH Aachen University, Germany.
¹⁴ Institute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, Germany (E.P.C.v.d.V.).
¹⁵ Department of Cardiology and Angiology (K.S.), Hannover Medical School, Germany.
¹⁶ Institute of Molecular and Translational Therapeutic Strategies (K.S.), Hannover Medical School, Germany.
¹⁷ Department of Vascular Medicine (B.J.H.V.), Amsterdam University Medical Centers, the Netherlands.
¹⁸ Department of Public and Occupational Health (B.J.H.V.), Amsterdam University Medical Centers, the Netherlands.
¹⁹ The Keenan Research Centre for Biomedical Science at St. Michael's, Toronto, Canada (W.M.K.).
²⁰ Departments of Surgery and Physiology, University of Toronto, Canada (W.M.K.).

PMID: 39351669
PMCID: PMC11542964
DOI: 10.1161/CIRCRESAHA.124.324938

Pneumonia Induced Rise in Glucagon Promotes Endothelial Damage and Thrombogenicity

Pegah Ramezani Rad et al. Circ Res. 2024.

. 2024 Nov 8;135(11):1116-1118.

doi: 10.1161/CIRCRESAHA.124.324938. Epub 2024 Oct 1.

Authors

Affiliations

¹ Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Berlin, Germany (P.R.R., V.N., L.R., J.R., E.A., R.S., U.L., A.H.).
² German Center for Cardiovascular Research, Berlin, Germany (P.R.R., V.N., L.P., L.R., J.R., S.S., C.W., R.S., U.L., W.M.K., A.H.).
³ Friede Springer-Cardiovascular Prevention Center at Charité, Charité-Universitätsmedizin Berlin, Germany (V.N., U.L., A.H.).
⁴ Institute of Chemistry and Biochemistry (V.N.), Freie Universität Berlin, Germany.
⁵ Department of Cardiology, University Hospital St Josef-Hospital Bochum, Ruhr University Bochum, Germany (V.N., L.R., J.R., A.H.).
⁶ Institute of Biology (L.P.), Freie Universität Berlin, Germany.
⁷ Institute of Physiology (L.P., S.S., E.A., W.M.K.), Charité-Universitätsmedizin Berlin, corporate member of the Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany.
⁸ Laboratory of In Vitro Modeling Systems of Pulmonary and Thrombotic Diseases, Institute of Physiology (C.W., R.S.), Charité-Universitätsmedizin Berlin, corporate member of the Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany.
⁹ German Center for Lung Research (DZL), Germany (C.W., R.S., M.W., W.M.K.).
¹⁰ Department of Infectious Diseases, Respiratory Medicine and Critical Care (M.C.B., G.N., M.W.), Charité-Universitätsmedizin Berlin, corporate member of the Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany.
¹¹ Institute for Molecular Cardiovascular Research (E.P.C.v.d.V., S.L.M.), RWTH Aachen University, Germany.
¹² Aachen-Maastricht Institute for CardioRenal Disease (E.P.C.v.d.V., S.L.M.), RWTH Aachen University, Germany.
¹³ Interdisciplinary Center for Clinical Research (E.P.C.v.d.V.), RWTH Aachen University, Germany.
¹⁴ Institute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, Germany (E.P.C.v.d.V.).
¹⁵ Department of Cardiology and Angiology (K.S.), Hannover Medical School, Germany.
¹⁶ Institute of Molecular and Translational Therapeutic Strategies (K.S.), Hannover Medical School, Germany.
¹⁷ Department of Vascular Medicine (B.J.H.V.), Amsterdam University Medical Centers, the Netherlands.
¹⁸ Department of Public and Occupational Health (B.J.H.V.), Amsterdam University Medical Centers, the Netherlands.
¹⁹ The Keenan Research Centre for Biomedical Science at St. Michael's, Toronto, Canada (W.M.K.).
²⁰ Departments of Surgery and Physiology, University of Toronto, Canada (W.M.K.).

PMID: 39351669
PMCID: PMC11542964
DOI: 10.1161/CIRCRESAHA.124.324938

No abstract available

Keywords: glucagon; injuries; pneumonia; thrombosis; vascular.

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Conflict of interest statement

None.

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1032 doi: 10.1161/RES.0000000000000700

References

1. Brown JS. Community-acquired pneumonia. Clin Med (Lond). 2012;12:538–543. doi: 10.7861/clinmedicine.12-6-538 - PMC - PubMed
1. Corrales-Medina VF, Alvarez KN, Weissfeld LA, Angus DC, Chirinos JA, Chang CCH, Newman A, Loehr L, Folsom AR, Elkind MS, et al. . Association between hospitalization for pneumonia and subsequent risk of cardiovascular disease. JAMA. 2015;313:264–274. doi: 10.1001/jama.2014.18229 - PMC - PubMed
1. Zhou G, Hamik A, Nayak L, Tian H, Shi H, Lu Y, Sharma N, Liao X, Hale A, Boerboom L, et al. . Endothelial Kruppel-like factor 4 protects against atherothrombosis in mice. J Clin Invest. 2012;122:4727–4731. doi: 10.1172/JCI66056 - PMC - PubMed

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Pneumonia Induced Rise in Glucagon Promotes Endothelial Damage and Thrombogenicity

Affiliations

Pneumonia Induced Rise in Glucagon Promotes Endothelial Damage and Thrombogenicity

Authors

Affiliations

Conflict of interest statement

Figures

Comment on

References

Publication types

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