Inflammation and aging-related disease: A transdisciplinary inflammaging framework

Brian J Andonian^#¹, Joseph A Hippensteel^#², Katrina Abuabara³, Eileen M Boyle⁴, James F Colbert⁵, Michael J Devinney⁶, Adam S Faye⁷, Bharati Kochar⁸, Jiha Lee⁹, Rachel Litke¹⁰, Devika Nair¹¹, Sebastian E Sattui¹², Anoop Sheshadri¹³, Andrea N Sherman¹⁴, Namrata Singh¹⁵, Yinan Zhang¹⁶, Sara C LaHue¹⁷

Affiliations

¹ Division of Rheumatology and Immunology, Duke University School of Medicine, Durham, NC, USA. brian.andonian@duke.edu.
² Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
³ Department of Dermatology, University of California San Francisco, San Francisco, CA, USA.
⁴ Department of Haematology, University College London Cancer Institute, London, UK.
⁵ Division of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
⁶ Division of Critical Care, Department of Anesthesiology, Duke University School of Medicine, Durham, NC, USA.
⁷ Division of Gastroenterology, Department of Population Health, NYU Langone Medical Center, New York, NY, USA.
⁸ Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA.
⁹ Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
¹⁰ Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
¹¹ Department of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN, USA.
¹² Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
¹³ Division of Nephrology, Department of Medicine, University of California, San Francisco, Nephrology Section, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
¹⁴ American Federation for Aging Research, New York, NY, USA.
¹⁵ Division of Rheumatology, University of Washington, Seattle, WA, USA.
¹⁶ Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
¹⁷ Department of Neurology, School of Medicine, and the UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.

^# Contributed equally.

PMID: 39352664
PMCID: PMC11872841
DOI: 10.1007/s11357-024-01364-0

Review

Inflammation and aging-related disease: A transdisciplinary inflammaging framework

Brian J Andonian et al. Geroscience. 2025 Feb.

. 2025 Feb;47(1):515-542.

doi: 10.1007/s11357-024-01364-0. Epub 2024 Oct 1.

Authors

Affiliations

¹ Division of Rheumatology and Immunology, Duke University School of Medicine, Durham, NC, USA. brian.andonian@duke.edu.
² Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
³ Department of Dermatology, University of California San Francisco, San Francisco, CA, USA.
⁴ Department of Haematology, University College London Cancer Institute, London, UK.
⁵ Division of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
⁶ Division of Critical Care, Department of Anesthesiology, Duke University School of Medicine, Durham, NC, USA.
⁷ Division of Gastroenterology, Department of Population Health, NYU Langone Medical Center, New York, NY, USA.
⁸ Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA.
⁹ Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
¹⁰ Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
¹¹ Department of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN, USA.
¹² Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
¹³ Division of Nephrology, Department of Medicine, University of California, San Francisco, Nephrology Section, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
¹⁴ American Federation for Aging Research, New York, NY, USA.
¹⁵ Division of Rheumatology, University of Washington, Seattle, WA, USA.
¹⁶ Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
¹⁷ Department of Neurology, School of Medicine, and the UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.

^# Contributed equally.

PMID: 39352664
PMCID: PMC11872841
DOI: 10.1007/s11357-024-01364-0

Abstract

Inflammaging, a state of chronic, progressive low-grade inflammation during aging, is associated with several adverse clinical outcomes, including frailty, disability, and death. Chronic inflammation is a hallmark of aging and is linked to the pathogenesis of many aging-related diseases. Anti-inflammatory therapies are also increasingly being studied as potential anti-aging treatments, and clinical trials have shown benefits in selected aging-related diseases. Despite promising advances, significant gaps remain in defining, measuring, treating, and integrating inflammaging into clinical geroscience research. The Clin-STAR Inflammation Research Interest Group was formed by a group of transdisciplinary clinician-scientists with the goal of advancing inflammaging-related clinical research and improving patient-centered care for older adults. Here, we integrate insights from nine medical subspecialties to illustrate the widespread impact of inflammaging on diseases linked to aging, highlighting the extensive opportunities for targeted interventions. We then propose a transdisciplinary approach to enhance understanding and treatment of inflammaging that aims to improve comprehensive care for our aging patients.

Keywords: Aging-related diseases; Cellular senescence; Geriatrics; Inflammaging; Internal medicine.

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Conflict of interest statement

Declarations. Competing interests: Sebastian E. Sattui: research funding from AstraZeneca and GlaxoSmithKline (clinical trials), consulting and advisory boards for Sanofi and Amgen (funds applied for research support), and speaker fees from Fresenius Kabi (funds applied for research support). Bharati Kochar: advisory boards for Pfizer, Inc. and Bristol Meyers Squibb. Adam S. Faye: consulting honoraria from Bristol Meyers Squibb, Abbvie, and Takeda. Michael J. Devinney: research funding from Merck Sharp & Dohme LLC (clinical trials). Sara C. LaHue: speaker honoraria from American Academy of Neurology and Medscape.

Figures

**Fig. 1**
Connecting inflammaging pathways and treatment strategies in aging-related disease

See this image and copyright information in PMC

References

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Inflammation and aging-related disease: A transdisciplinary inflammaging framework

Affiliations

Inflammation and aging-related disease: A transdisciplinary inflammaging framework

Authors

Affiliations

Abstract

Conflict of interest statement

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Medical