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. 2024 Sep;177(5):678-681.
doi: 10.1007/s10517-024-06248-z. Epub 2024 Oct 1.

Characteristics of Psychoemotional Manifestations of Laboratory Rodents Undergoing Surgery when Modeling Preoperative Stress

M V Kondashevskaya  1 , V V Aleksankina  2 , K A Artemyeva  2 , K A Kasabov  2
Affiliations

Characteristics of Psychoemotional Manifestations of Laboratory Rodents Undergoing Surgery when Modeling Preoperative Stress

M V Kondashevskaya et al. Bull Exp Biol Med. 2024 Sep.

Abstract

We studied psychoemotional characteristics and the blood level of corticosterone in sexually mature male C57BL/6 mice (n=40): intact (control), after simulating preoperative stress and surgery, after surgery, and after anesthesia alone. It was found that the anxiety index calculated on the basis of testing in the elevated plus maze was significantly higher in both groups of operated animals. The mice of both operated groups and animals exposed to anesthesia alone showed increased anxiety. Symptoms indicating a high probability of transition of anxiety into a psychoemotional disorder have been recorded.

Keywords: C57BL/6 mice; anesthesia; stress disorder; surgery.

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