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. 2024 Nov;32(11):1042-1044.
doi: 10.1016/j.tim.2024.09.008. Epub 2024 Oct 1.

Heteroresistance: a hidden cause behind antifungal prophylaxis failure

Anaïs Hérivaux  1 , Nicolas Papon  1 , Florent Morio  2
Affiliations

Heteroresistance: a hidden cause behind antifungal prophylaxis failure

Anaïs Hérivaux et al. Trends Microbiol. 2024 Nov.

Abstract

Invasive fungal infections in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients on antimicrobial prophylaxis is a major cause of infectious mortality, although its underlying pathophysiological mechanisms remain unclear. In a new report, Zhai and colleagues provide evidence that heteroresistance drives breakthrough Candida parapsilosis bloodstream infections in allo-HSCT recipients receiving micafungin prophylaxis.

Keywords: Candida; antifungal; breakthrough infections; diagnosis; heteroresistance.

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Conflict of interest statement

Declaration of interests No interests are declared.

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