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Case Reports
. 2024 Sep 28;16(9):446-452.
doi: 10.4329/wjr.v16.i9.446.

Myelin oligodendrocyte glycoprotein-associated transverse myelitis after SARS-CoV-2 infection: A case report

Jian-Rong Zheng  1   2 , Jun-Lei Chang  3 , Jun Hu  1 , Zhi-Jian Lin  1 , Kai-Hua Lin  1 , Bi-Hua Lu  4 , Xu-Hui Chen  5 , Zhi-Gang Liu  6
Affiliations
Case Reports

Myelin oligodendrocyte glycoprotein-associated transverse myelitis after SARS-CoV-2 infection: A case report

Jian-Rong Zheng et al. World J Radiol. .

Abstract

Background: Cases of myelin oligodendrocyte glycoprotein (MOG) antibody-related disease have a history of coronavirus disease 2019 infection or its vaccination before disease onset. Severe acute respiratory syndrome virus 2 (SARS-CoV-2) infection has been considered to be a trigger of central nervous system autoimmune diseases.

Case summary: Here we report a 20-year male with MOG-associated transverse myelitis after a SARS-CoV-2 infection. The patient received a near-complete recovery after standard immunological treatments.

Conclusion: Attention should be paid to the evaluation of typical or atypical neurological symptoms that may be triggered by SARS-CoV-2 infection.

Keywords: COVID-19; Case report; Myelin oligodendrocyte glycoprotein antibody-associated disease; Myelin oligodendrocyte glycoprotein antibody-associated encephalomyelitis; SARS-CoV-2.

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Conflict of interest statement

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
A magnetic resonance imaging scan of the thoracic spinal cord of the patient before treatment. A: Sagittal T1WI sequence of the cervical spine; B: The sagittal T2WI-FS sequence of the cervical spine shows hyperintensity in the long central segment of the spinal cord C3-C6 (arrow); C: Axial T2WI sequence of the cervical spine shows hyperintensity in the central spinal cord at the C3-C6 level (arrow); D: Sagittal T1WI sequence of the lumbar spine; E: Sagittal T2WI sequence of the lumbar spine shows hyperintensity from the central long segment of the T7-T8 spinal cord (arrow); F: Axial T2WI sequence of the lumbar spine shows hyperintensity at the T7-T8 level (arrow).
Figure 2
Figure 2
A chest computerized tomography scan of the patient. Chest computerized tomography showed mild interstitial lesions in both lower lungs without the typical ground glass-like or solid shadows of severe acute respiratory syndrome virus 2 infection.
Figure 3
Figure 3
Magnetic resonance imaging scan of spinal cord one week after methylprednisolone treatment. A: Sagittal T2WI sequence of the cervical spine shows a reduced range of long T2 signals in C3-C6 and T7-T8 segments compared with the previous one (arrows); B: Sagittal T2WI sequence of the lumbar spine: A reduced range of long T2 signals in T7-T8 segments compared with the previous one (arrows); C: Sagittal enhancement sequence of the cervical spine: No abnormal enhancement was seen; D: Sagittal enhancement sequence of the lumbar spine: No abnormal enhancement was seen.
See this image and copyright information in PMC

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