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Meta-Analysis
. 2024 Aug 28:13:976.
doi: 10.12688/f1000research.153743.1. eCollection 2024.

The Association between Early-Onset Pancreatic Ductal Adenocarcinoma and Patients Survival: A Systematic Review and Meta-Analysis

Kaka Renaldi  1 , Andy William  2
Affiliations
Meta-Analysis

The Association between Early-Onset Pancreatic Ductal Adenocarcinoma and Patients Survival: A Systematic Review and Meta-Analysis

Kaka Renaldi et al. F1000Res. .

Abstract

Background: In recent years, the incidence of early-onset pancreatic cancer (EOPC) has increased. Several studies comparing the survival of patients with EOPC to those with average-onset pancreatic cancer (AOPC) have reported mixed results. We aimed, therefore, to perform a meta-analysis summarizing the current evidence.

Methods: We searched the MEDLINE and EMBASE databases for relevant articles published through March 2024. Articles comparing the survival of patients with EOPC - defined as pancreatic ductal adenocarcinoma (PDAC) diagnosed at ≤ 50 years of age - and AOPC were included in the present meta-analysis. The primary outcome was the pooled adjusted hazard ratio (aHR), and the risk of bias analysis was performed using the Quality in Prognostic Factor Studies tool. The meta-analysis was performed using a random-effects model.

Results: A total of 17 studies were eligible for the primary analysis, the results of which indicated that patients with EOPC had a longer overall survival than those with AOPC (aHR = 0.80; 95% confidence interval [CI], 0.74-0.86; P < 0.001). The rate of distant metastasis was higher in EOPC than AOPC; however, patients with EOPC also received more treatments than those with AOPC.

Conclusions: Patients with EOPC had a better prognosis than those with AOPC. Clinicians must ensure that patients with PDAC receive early and appropriate treatment to improve their survival.

Keywords: Meta-analysis; Pancreatic neoplasms; Survival; Young adult.

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Conflict of interest statement

No competing interests were disclosed.

Figures

Figure 1.
Figure 1.. PRISMA study flow diagram.
Figure 2.
Figure 2.. Forest plot of overall survival analysis between EOPC and AOPC patients.
Figure 3.
Figure 3.. Forest plot of subgroup overall survival analysis between EOPC and AOPC patients who received surgery.
See this image and copyright information in PMC

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