Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Sep 30:32:e20240206.
doi: 10.1590/1678-7757-2024-0206. eCollection 2024.

Clinical response to nonsurgical periodontal therapy is associated with decreased serum leukocyte count and uric acid levels in kidney transplant recipients

Samira Vasconcelos Gomes  1 , Danila Lorena Nunes-Dos-Santos  2 , Luciana Salles Branco-De-Almeida  1 , Bruno Braga Benatti  1 , Vandilson Rodrigues  1
Affiliations

Clinical response to nonsurgical periodontal therapy is associated with decreased serum leukocyte count and uric acid levels in kidney transplant recipients

Samira Vasconcelos Gomes et al. J Appl Oral Sci. .

Abstract

Objective: This study sought to investigate the relationship between clinical response to nonsurgical periodontal therapy (NSPT) and serum changes in leukocyte count, fasting blood glucose, hemoglobin, hematocrit, creatinine, and uric acid in kidney transplant recipients (KTR).

Methodology: A prospective study was performed on 20 KTRs. Periodontal and serum data were collected before and 90 days after NSPT, and delta values (Δ = after NSPT - before) were calculated. Periodontal assessment included periodontal probing depth (PPD), clinical attachment level (CAL), and bleeding on probing (BOP). Patients were classified based on the presence of periodontitis and then categorized into stages.

Results: Patients showed a reduction in the percentage of sites with PPD≥3mm, PPD≥4 mm and BOP, after NSPT. There was a direct correlation between the deltas of leukocyte count and CAL ≥3 mm (r=0.645, P=0.002) and BOP (r=0.663, P=0.001), and the deltas of uric acid and CAL ≥3 mm (r=0.562, P=0.010).

Conclusion: A good clinical response to NSPT may affect the reduction of serum levels of leukocyte count and uric acid, suggesting a beneficial effect on systemic health in KTR.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: The authors declare no conflict of interest.

Figures

Figure 1
Figure 1. Flowchart of the screening process of study participants. NSPT: non-surgical periodontal therapy. BMI: Body mass index.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Kovesdy CP. Epidemiology of chronic kidney disease: an update 2022. Kidney Int Suppl (2011) 2022;12(1):7–11. doi: 10.1016/j.kisu.2021.11.003. - DOI - PMC - PubMed
    1. Webster AC, Nagler EV, Morton RL, Masson P. Chronic kidney disease. Lancet. 2017;389(10075):1238–1252. doi: 10.1016/S0140-6736(16)32064-5. - DOI - PubMed
    1. Schoot TS, Goto NA, van Marum RJ, Hilbrands LB, Kerckhoffs AP. Dialysis or kidney transplantation in older adults? A systematic review summarizing functional, psychological, and quality of life-related outcomes after start of kidney replacement therapy. Int Urol Nephrol. 2022;54(11):2891–2900. doi: 10.1007/s11255-022-03208-2. - DOI - PMC - PubMed
    1. Guha C, van Zwieten A, Khalid R, Kim S, Walker A, Francis A, et al. Longitudinal assessment of the health-related quality of life of children and adolescents with chronic kidney disease. Kidney Int. 2023;103(2):357–364. doi: 10.1016/j.kint.2022.09.026. - DOI - PubMed
    1. Tonetti MS, Greenwell H, Kornman KS. Staging and grading of periodontitis: framework and proposal of a new classification and case definition. J Periodontol. 2018;89(Suppl 1):S159–S172. doi: 10.1002/JPER.18-0006. - DOI - PubMed

MeSH terms