HumanIslets.com: Improving accessibility, integration, and usability of human research islet data

Jessica D Ewald¹, Yao Lu², Cara E Ellis³, Jessica Worton⁴, Jelena Kolic⁵, Shugo Sasaki⁶, Dahai Zhang⁶, Theodore Dos Santos³, Aliya F Spigelman³, Austin Bautista⁷, Xiao-Qing Dai³, James G Lyon⁷, Nancy P Smith³, Jordan M Wong⁴, Varsha Rajesh⁸, Han Sun⁸, Seth A Sharp⁸, Jason C Rogalski⁹, Renata Moravcova⁹, Haoning H Cen⁵, Jocelyn E Manning Fox³; HumanIslets.com Consortium; Ella Atlas¹⁰, Jennifer E Bruin¹¹, Erin E Mulvihill¹², C Bruce Verchere¹³, Leonard J Foster⁹, Anna L Gloyn¹⁴, James D Johnson⁵, Andrew R Pepper⁴, Francis C Lynn⁶, Jianguo Xia¹⁵, Patrick E MacDonald¹⁶

Affiliations

¹ Institute of Parasitology, McGill University, Montreal, QC, Canada; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
² Institute of Parasitology, McGill University, Montreal, QC, Canada.
³ Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada.
⁴ Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Department of Surgery, University of Alberta, Edmonton, AB, Canada.
⁵ Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.
⁶ Diabetes Research Group, BC Children's Hospital Research Institute, Vancouver, BC, Canada; Department of Surgery, School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada.
⁷ Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada.
⁸ Department of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford, CA, USA.
⁹ Department of Biochemistry & Molecular Biology, Michael Smith Laboratories, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.
¹⁰ Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada.
¹¹ Department of Biology & Institute of Biochemistry, Carleton University, Ottawa, ON, Canada.
¹² Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada; University of Ottawa Heart Institute, Ottawa, ON, Canada.
¹³ Department of Surgery, BC Children's Hospital Research Institute and University of British Columbia, Vancouver, BC, Canada; Department of Pathology and Laboratory Medicine, BC Children's Hospital Research Institute and University of British Columbia, Vancouver, BC, Canada; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada.
¹⁴ Department of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford, CA, USA; Stanford Diabetes Research Center, Stanford School of Medicine, Stanford, CA, USA; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA.
¹⁵ Institute of Parasitology, McGill University, Montreal, QC, Canada. Electronic address: jeff.xia@mcgill.ca.
¹⁶ Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada; Division of Metabolism, Endocrinology & Diabetes, University of Michigan, Ann Arbor, MI, USA. Electronic address: pmacdonald@ualberta.ca.

PMID: 39357523
DOI: 10.1016/j.cmet.2024.09.001

HumanIslets.com: Improving accessibility, integration, and usability of human research islet data

Jessica D Ewald et al. Cell Metab. 2025.

. 2025 Jan 7;37(1):7-11.

doi: 10.1016/j.cmet.2024.09.001. Epub 2024 Oct 1.

Authors

Affiliations

¹ Institute of Parasitology, McGill University, Montreal, QC, Canada; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
² Institute of Parasitology, McGill University, Montreal, QC, Canada.
³ Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada.
⁴ Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Department of Surgery, University of Alberta, Edmonton, AB, Canada.
⁵ Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.
⁶ Diabetes Research Group, BC Children's Hospital Research Institute, Vancouver, BC, Canada; Department of Surgery, School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada.
⁷ Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada.
⁸ Department of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford, CA, USA.
⁹ Department of Biochemistry & Molecular Biology, Michael Smith Laboratories, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.
¹⁰ Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada.
¹¹ Department of Biology & Institute of Biochemistry, Carleton University, Ottawa, ON, Canada.
¹² Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada; University of Ottawa Heart Institute, Ottawa, ON, Canada.
¹³ Department of Surgery, BC Children's Hospital Research Institute and University of British Columbia, Vancouver, BC, Canada; Department of Pathology and Laboratory Medicine, BC Children's Hospital Research Institute and University of British Columbia, Vancouver, BC, Canada; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada.
¹⁴ Department of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford, CA, USA; Stanford Diabetes Research Center, Stanford School of Medicine, Stanford, CA, USA; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA.
¹⁵ Institute of Parasitology, McGill University, Montreal, QC, Canada. Electronic address: jeff.xia@mcgill.ca.
¹⁶ Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada; Division of Metabolism, Endocrinology & Diabetes, University of Michigan, Ann Arbor, MI, USA. Electronic address: pmacdonald@ualberta.ca.

PMID: 39357523
DOI: 10.1016/j.cmet.2024.09.001

Abstract

HumanIslets.com supports diabetes research by offering easy access to islet phenotyping data, analysis tools, and data download. It includes molecular omics, islet and cellular function assays, tissue processing metadata, and phenotypes from 547 donors. As it expands, the resource aims to improve human islet data quality, usability, and accessibility.

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Conflict of interest statement

Declaration of interests A.L.G.’s spouse is an employee of Genentech and holds stock options in Roche. A.R.P. serves on the Scientific Advisory Committee for Encellin Inc. J.X. is founder of XiaLab Analytics, which provides omics data science training and support.

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HumanIslets.com: Improving accessibility, integration, and usability of human research islet data

Affiliations

HumanIslets.com: Improving accessibility, integration, and usability of human research islet data

Authors

Affiliations

Abstract

Conflict of interest statement

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Research Materials