Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Jan;102(1):31-43.
doi: 10.1111/cen.15139. Epub 2024 Oct 3.

Adrenal Vein Sampling for Primary Aldosteronism: Recommendations From the Australian and New Zealand Working Group

Affiliations
Review

Adrenal Vein Sampling for Primary Aldosteronism: Recommendations From the Australian and New Zealand Working Group

Jun Yang et al. Clin Endocrinol (Oxf). 2025 Jan.

Abstract

Adrenal vein sampling (AVS) is the current recommended procedure for identifying unilateral subtypes of primary aldosteronism (PA), which are amenable to surgery with the potential for cure. AVS is a technically challenging procedure usually undertaken by interventional radiologists at tertiary centres. However, there are numerous variations in AVS protocols relating to patient preparation, sampling techniques and interpretation which may impact the success of AVS and patient care. To reduce practice variations, improve the success rates of AVS and optimise patient outcomes, we established an Australian and New Zealand AVS Working Group and developed evidence-based expert consensus recommendations for the preparation, performance and interpretation of AVS. These recommendations can be used by all healthcare professionals in a multidisciplinary team who look after the diagnosis and management of PA.

Keywords: adrenal vein sampling; conn syndrome; endocrine hypertension; hyperaldosteronism; hypertension; primary aldosteronism; subtyping.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Adrenal vein sampling—plain language information for patients.
Figure 1
Figure 1
Adrenal vein sampling—plain language information for patients.

References

    1. Samnani S., Cenzer I., Kline G. A., et al., “Time to Benefit of Surgery vs. Targeted Medical Therapy for Patients With Primary Aldosteronism: A Meta‐Analysis,” Journal of Clinical Endocrinology and Metabolism 109, no. 3 (2024): e1280–e1289. - PMC - PubMed
    1. Funder J. W., Carey R. M., Mantero F., et al., “The Management of Primary Aldosteronism: Case Detection, Diagnosis, and Treatment: An Endocrine Society Clinical Practice Guideline,” Journal of Clinical Endocrinology & Metabolism 101, no. 5 (2016): 1889–1916. - PubMed
    1. Muhamad Pauzi K. N., Zakaria R., Leong Y. Y., Nik Fuad N. F., Nik Ismail N. A., and Sukor N., “Success Rate of Adrenal Venous Sampling and Its Determining Factors: Experience of a Single Center in Malaysia,” Annals of Vascular Surgery 98 (2024): 258–267. - PubMed
    1. Rossi G. P., Barisa M., Allolio B., et al., “The Adrenal Vein Sampling International Study (AVIS) for Identifying the Major Subtypes of Primary Aldosteronism,” Journal of Clinical Endocrinology & Metabolism 97, no. 5 (2012): 1606–1614. - PubMed
    1. Ng E., Chong W., Lau K. K., et al., “The Where, Who and How of Adrenal Vein Sampling in Australia and New Zealand,” Journal of Medical Imaging and Radiation Oncology 68, no. 1 (2024): 87–93. - PubMed

LinkOut - more resources