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Review
. 2024 Nov 1;40(6):464-469.
doi: 10.1097/MOG.0000000000001048. Epub 2024 Jun 14.

Celiac disease and nonceliac enteropathies

John B Doyle  1 , Benjamin Lebwohl  1   2
Affiliations
Review

Celiac disease and nonceliac enteropathies

John B Doyle et al. Curr Opin Gastroenterol. .

Abstract

Purpose of review: This review highlights recent research in the field of celiac disease.

Recent findings: Epidemiological studies continue to identify celiac disease-associated diseases such as inflammatory arthritis, irritable bowel syndrome, and cardiovascular disease. Recently published consensus guidelines provide recommendations for the long-term management and monitoring of patients with celiac disease. There are multiple pharmaceutical therapies for celiac disease under investigation, and recent phase I and phase II trials are reviewed here. Finally, a recent trial of patients with nonceliac gluten sensitivity demonstrates a significant nocebo effect in this condition.

Summary: Recent advances in celiac disease include the development of new clinical guidelines as well as promising new therapeutics. Continued high-quality research is needed to improve the outcomes of patients with celiac disease and nonceliac enteropathies.

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Conflict of interest statement

Conflicts of interest: none

References

    1. Rubio-Tapia A, Ludvigsson JF, Brantner TL, et al. The prevalence of celiac disease in the United States. Am J Gastroenterol. 2012;107(10):1538–44; quiz 7, 45. - PubMed
    1. Choung RS, Larson SA, Khaleghi S, et al. Prevalence and Morbidity of Undiagnosed Celiac Disease From a Community-Based Study. Gastroenterology. 2017;152(4):830–9 e5. - PMC - PubMed
    1. King JA, Jeong J, Underwood FE, et al. Incidence of Celiac Disease Is Increasing Over Time: A Systematic Review and Meta-analysis. Am J Gastroenterol. 2020;115(4):507–25. - PubMed
    1. King JA, Bakal JA, Li B, et al. Variation in Testing for and Incidence of Celiac Autoimmunity in Canada: A Population-Based Study. Gastroenterology. 2023;164(4):567–78 e7. - PubMed
    1. Schiepatti A, Maimaris S, Lusetti F, et al. High Prevalence of Functional Gastrointestinal Disorders in Celiac Patients with Persistent Symptoms on a Gluten-Free Diet: A 20-Year Follow-Up Study. Dig Dis Sci. 2023;68(8):3374–82. - PMC - PubMed

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