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Review
. 2024 Nov 1;40(6):470-476.
doi: 10.1097/MOG.0000000000001045. Epub 2024 Jun 12.

Current opinion: functional dyspepsia

Caroline G Olson  1 , Paul Travers  1 , Brian E Lacy  2
Affiliations
Review

Current opinion: functional dyspepsia

Caroline G Olson et al. Curr Opin Gastroenterol. .

Abstract

Purpose of review: Functional dyspepsia is a common gastrointestinal disease that is under-recognized and under-diagnosed. It is a complex disorder of gut-brain interaction with no FDA-approved treatment options. The purpose of this review is to highlight updates in the proposed pathophysiology and present new data regarding potential therapies for functional dyspepsia.

Recent findings: Alterations in the intestinal microbiome and integrity of the intestinal membrane may play a crucial role in the pathogenesis of functional dyspepsia. The low FODMAP diet, in addition to modulating the microbiome with antibiotics and probiotics, are targets for large future studies. Novel methods of delivery of gut-brain therapies have shown promising results, especially virtual reality.

Summary: The pathophysiology and management of functional dyspepsia is complex and there is still much unknown; however, continued research is identifying new targets for treatment. New and more targeted treatment options provide clinicians a variety of tools to offer patients with functional dyspepsia.

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References

    1. Sperber AD, Bangdiwala SI, Drossman DA, et al. Worldwide prevalence and burden of functional gastrointestinal disorders, results of Rome Foundation global study. Gastroenterology 2021; 160:99–114.
    1. Arnaout AY, Alhejazi TJ, Nerabani Y, et al. PRIBS Study Team. The prevalence and risk factors of functional dyspepsia among adults in low and middle income countries: an international cross-sectional study. Medicine 2023; 102:40.
    1. Stanghellini V, Chan FKL, Hasler WL, et al. Gastroduodenal disorders. Gastroenterology 2016; 150:1380–1392.
    1. Ford AC, Mahadeva S, Carbone MF, et al. Functional dyspepsia. Lancet 2020; 396:1689–1702.
    1. Cangemi D, Stephens L, Lacy BE. Diagnosis of gastroparesis is common: a retrospective review of patients referred to a tertiary gastroenterology practice. Clin Gastroenterol Hepatol 2023; 21:2670–2672.

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