Biomarker-Based Approach to α-Synucleinopathies: Lessons from Neuropathology

Gabor G Kovacs¹, Lea T Grinberg^{2

3}, Glenda Halliday^{4

5}, Irina Alafuzoff⁶, Brittany N Dugger⁷, Shigeo Murayama⁸, Shelley L Forrest¹, Ivan Martinez-Valbuena¹, Hidetomo Tanaka¹, Tomoya Kon⁹, Koji Yoshida¹, Zane Jaunmuktane¹⁰, Salvatore Spina², Peter T Nelson¹¹, Steve Gentleman¹², Javier Alegre-Abarrategui¹², Geidy E Serrano¹³, Vitor Ribeiro Paes³, Masaki Takao¹⁴, Koichi Wakabayashi¹⁵, Toshiki Uchihara¹⁶, Mari Yoshida¹⁷, Yuko Saito⁸, Julia Kofler¹⁸, Roberta Diehl Rodriguez¹⁹, Ellen Gelpi²⁰, Johannes Attems²¹, John F Crary²², William W Seeley², John E Duda²³, C Dirk Keene²⁴, John Woulfe²⁵, David Munoz²⁶, Colin Smith²⁷, Edward B Lee²⁸, Manuela Neumann²⁹, Charles L White 3rd³⁰, Ann C McKee³¹, Dietmar R Thal^{32

33}, Kurt Jellinger³⁴, Bernardino Ghetti³⁵, Ian R A Mackenzie³⁶, Dennis W Dickson³⁷, Thomas G Beach¹³

Affiliations

¹ Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.
² Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco (UCSF), San Francisco, California, USA.
³ Department of Pathology, University of São Paulo Medical School, São Paulo, Brazil.
⁴ Brain and Mind Centre, The University of Sydney, Sydney, Australia.
⁵ School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
⁶ Surgical Pathology, Uppsala University Hospital, Uppsala, Sweden.
⁷ University of California Davis Health, Sacramento, California, USA.
⁸ Brain Bank for Aging Research, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.
⁹ Department of Neurology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
¹⁰ Department of Clinical and Movement Neurosciences, Queen Square Brain Bank for Neurological Disorders, Queen Square Institute of Neurology, University College London, London, United Kingdom.
¹¹ Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.
¹² Imperial College London, Parkinson's UK Tissue Bank, London, United Kingdom.
¹³ Banner Sun Health Research Institute, Sun City, Arizona, USA.
¹⁴ Department of Clinical Laboratory and Internal Medicine, National Center of Neurology and Psychiatry (NCNP), National Center Hospital, Tokyo, Japan.
¹⁵ Department of Neuropathology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
¹⁶ University of Hawaii Postgraduate Medical Education Program at Okinawa Chubu Hospital, Uruma, Japan.
¹⁷ Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Aichi, Japan.
¹⁸ Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
¹⁹ Laboratorio de Ressonancia Magnetica em Neurorradiologia (LIM-44), HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
²⁰ Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, Vienna, Austria.
²¹ Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
²² Departments of Pathology, Neuroscience, and Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
²³ Michael J. Crescenz VA Medical Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
²⁴ Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington, USA.
²⁵ Ottawa Hospital Research Institute and University of Ottawa, Ottawa, Ontario, Canada.
²⁶ St. Michael's Hospital, Toronto, Ontario, Canada.
²⁷ University of Edinburgh, Academic Department of Neuropathology, Centre for Clinical Brain Sciences, Edinburgh, United Kingdom.
²⁸ Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
²⁹ Department of Neuropathology, University Hospital Tübingen and DZNE Tübingen, Tübingen, Germany.
³⁰ Neuropathology Section, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
³¹ Boston University Alzheimer's Disease Center and CTE Center, Boston, Massachusetts, USA.
³² Laboratory of Neuropathology, Department of Imaging and Pathology and Leuven Brain Institute, KU-Leuven, Leuven, Belgium.
³³ Department of Pathology, University Hospital Leuven, Leuven, Belgium.
³⁴ Institute of Clinical Neurobiology, Vienna, Austria.
³⁵ School of Medicine, Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana, USA.
³⁶ Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada.
³⁷ Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.

PMID: 39360851
PMCID: PMC11657033
DOI: 10.1002/mds.30028

Biomarker-Based Approach to α-Synucleinopathies: Lessons from Neuropathology

Gabor G Kovacs et al. Mov Disord. 2024 Dec.

. 2024 Dec;39(12):2173-2179.

doi: 10.1002/mds.30028. Epub 2024 Oct 3.

Authors

Affiliations

¹ Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.
² Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco (UCSF), San Francisco, California, USA.
³ Department of Pathology, University of São Paulo Medical School, São Paulo, Brazil.
⁴ Brain and Mind Centre, The University of Sydney, Sydney, Australia.
⁵ School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
⁶ Surgical Pathology, Uppsala University Hospital, Uppsala, Sweden.
⁷ University of California Davis Health, Sacramento, California, USA.
⁸ Brain Bank for Aging Research, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.
⁹ Department of Neurology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
¹⁰ Department of Clinical and Movement Neurosciences, Queen Square Brain Bank for Neurological Disorders, Queen Square Institute of Neurology, University College London, London, United Kingdom.
¹¹ Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.
¹² Imperial College London, Parkinson's UK Tissue Bank, London, United Kingdom.
¹³ Banner Sun Health Research Institute, Sun City, Arizona, USA.
¹⁴ Department of Clinical Laboratory and Internal Medicine, National Center of Neurology and Psychiatry (NCNP), National Center Hospital, Tokyo, Japan.
¹⁵ Department of Neuropathology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
¹⁶ University of Hawaii Postgraduate Medical Education Program at Okinawa Chubu Hospital, Uruma, Japan.
¹⁷ Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Aichi, Japan.
¹⁸ Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
¹⁹ Laboratorio de Ressonancia Magnetica em Neurorradiologia (LIM-44), HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
²⁰ Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, Vienna, Austria.
²¹ Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
²² Departments of Pathology, Neuroscience, and Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
²³ Michael J. Crescenz VA Medical Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
²⁴ Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington, USA.
²⁵ Ottawa Hospital Research Institute and University of Ottawa, Ottawa, Ontario, Canada.
²⁶ St. Michael's Hospital, Toronto, Ontario, Canada.
²⁷ University of Edinburgh, Academic Department of Neuropathology, Centre for Clinical Brain Sciences, Edinburgh, United Kingdom.
²⁸ Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
²⁹ Department of Neuropathology, University Hospital Tübingen and DZNE Tübingen, Tübingen, Germany.
³⁰ Neuropathology Section, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
³¹ Boston University Alzheimer's Disease Center and CTE Center, Boston, Massachusetts, USA.
³² Laboratory of Neuropathology, Department of Imaging and Pathology and Leuven Brain Institute, KU-Leuven, Leuven, Belgium.
³³ Department of Pathology, University Hospital Leuven, Leuven, Belgium.
³⁴ Institute of Clinical Neurobiology, Vienna, Austria.
³⁵ School of Medicine, Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana, USA.
³⁶ Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada.
³⁷ Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.

PMID: 39360851
PMCID: PMC11657033
DOI: 10.1002/mds.30028

No abstract available

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References

1. Simuni T, Chahine LM, Poston K, et al. A biological definition of neuronal alpha‐synuclein disease: towards an integrated staging system for research. Lancet Neurol 2024;23(2):178–190. - PubMed
1. Hoglinger GU, Adler CH, Berg D, et al. A biological classification of Parkinson's disease: the SynNeurGe research diagnostic criteria. Lancet Neurol 2024;23(2):191–204. - PubMed
1. Lewy F, Paralysis agitans I. Pathologische Anatomie. In: Lewandowsky M, Abelsdorff G, eds. Handbuch der Neurologie. Vol. 3. Berlin: Springer Verlag; 1912:920–933.
1. Papp MI, Kahn JE, Lantos PL. Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and shy‐Drager syndrome). J Neurol Sci 1989;94(1–3):79–100. - PubMed
1. Goedert M, Jakes R, Spillantini MG. The synucleinopathies: twenty years on. J Parkinsons Dis 2017;7(s1):S51–S69. - PMC - PubMed

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Biomarker-Based Approach to α-Synucleinopathies: Lessons from Neuropathology

Affiliations

Biomarker-Based Approach to α-Synucleinopathies: Lessons from Neuropathology

Authors

Affiliations

References

Grants and funding

LinkOut - more resources

Full Text Sources