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. 2024 Nov 19;332(19):1669-1672.
doi: 10.1001/jama.2024.20951.

Decline of Mpox Antibody Responses After Modified Vaccinia Ankara-Bavarian Nordic Vaccination

Ai-Ris Y Collier  1 , Katherine McMahan  1 , Catherine Jacob-Dolan  1 , Jinyan Liu  1 , Erica N Borducchi  1 , Bernard Moss  2 , Dan H Barouch  1
Affiliations

Decline of Mpox Antibody Responses After Modified Vaccinia Ankara-Bavarian Nordic Vaccination

Ai-Ris Y Collier et al. JAMA. .
No abstract available

Plain language summary

This study assesses mpox-specific immune responses for 12 months after MVA-BN vaccination.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Collier reported grants from the Massachusetts Consortium on Pathogen Readiness (MassCPR) during the conduct of the study. Dr Barouch reported grants from the Biomedical Advanced Research and Development Authority, Defense Advanced Research Projects Agency, Bill & Melinda Gates Foundation, Henry M. Jackson Foundation, MassCPR, National Cancer Institute, National Institute of Allergy and Infectious Diseases (NIAID), Ragon Institute, South African Medical Research Council, Walter Reed Army Institute of Research, Alkermes, CureVac, Gilead, Gritstone, GSK, Hookipa, Intima, Janssen, Legend, Leyden Labs, Musk Foundation, Novavax, Pfizer, Pharm-Olam, Sanofi, and Zentalis; equity in Celsion/Imunon; and consulting fees from Avidea, Celsion/Imunon, Laronde, Meissa, SQZ, and Sterne Kessler; and is the founder of and has equity in Vector Sciences outside the submitted work. No other disclosures were reported.

Figures

Figure.
Figure.. Serum Mpox Antibody Responses After 2-Dose and 1-Dose Modified Vaccinia Ankara–Bavarian Nordic (MVA-BN) Vaccination Over Time
Mpox-specific enzyme-linked immunosorbent assay (ELISA) (A and B) and 50% neutralizing antibody (NAb) titers (NT50) (C). Peak immunity was defined as 3 weeks after final vaccination. Titers less than 30 are considered negative. Horizontal red bars reflect median values. Numbers above the antigen data points reflect median titers.
See this image and copyright information in PMC

Update of

References

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