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Editorial
. 2024 Dec;15(12):1707-1710.
doi: 10.1111/jdi.14295. Epub 2024 Oct 3.

The roles of output clock genes in regulating glucose metabolism

Akihiko Taguchi #  1 , Yasuharu Ohta #  1 , Yuko Nagao  2 , Yukio Tanizawa  3
Affiliations
Editorial

The roles of output clock genes in regulating glucose metabolism

Akihiko Taguchi et al. J Diabetes Investig. 2024 Dec.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Yukio Tanizawa is an Editorial Board member of Journal of Diabetes Investigation and a co‐author of this article. To minimize bias, he was excluded from all editorial decision‐making related to the acceptance of this article for publication.

Figures

Figure 1
Figure 1
The core transcription–translation feedback loop of the circadian clock. BMAL1/CLOCK binds to the E‐box and enhances the expressions of Pers and Crys. Translated PERs and CRYS suppress their own gene expressions by inhibiting CLOCK‐BMAL1‐mediated transcription.
Figure 2
Figure 2
Schema of transcriptional regulation mechanism from core clock and stabilizing loops to clock‐controlled genes via clock output genes. Core loop signals regulate Dbp expression via E‐box elements, and stabilizing signals regulate E4BP4 expression via RRE elements. DBP and E4BP4 regulate downstream clock control genes by binding to the D‐box as transcriptional activators and repressors, respectively. Circadian disruption signals are transmitted to Coreloop, while meal and endoplasmic reticulum stress stimuli are thought to be transmitted to clock output genes.
See this image and copyright information in PMC

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