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Review
. 2024 Sep 19:15:1464135.
doi: 10.3389/fmicb.2024.1464135. eCollection 2024.

Significance of research on natural products from marine-derived Aspergillus species as a source against pathogenic bacteria

Bin Wang #  1   2 , Jin Cai #  1   2 , Longtao Huang  1   2 , Yonghao Chen  1   2 , Ruoxi Wang  1   2 , Mengyao Luo  1   2 , Meng Yang  1   2 , Mohan Zhang  1   2 , Nasihat  1   2 , Guangying Chen  1   2 , Guolei Huang  1   2 , Caijuan Zheng  1   2
Affiliations
Review

Significance of research on natural products from marine-derived Aspergillus species as a source against pathogenic bacteria

Bin Wang et al. Front Microbiol. .

Abstract

Bacterial infections pose a significant clinical burden on global health. The growing incidence of drug-resistant pathogens highlights the critical necessity to identify and isolate bioactive compounds from marine resources. Marine-derived fungi could provide novel lead compounds against pathogenic bacteria. Due to the particularity of the marine environment, Aspergillus species derived from marine sources have proven to be potent producers of bioactive secondary metabolites and have played a considerable role in advancing drug development. This study reviews the structural diversity and activities against pathogenic bacteria of secondary metabolites isolated from marine-derived Aspergillus species over the past 14 years (January 2010-June 2024), and 337 natural products (including 145 new compounds) were described. The structures were divided into five major categories-terpenoids, nitrogen-containing compounds, polyketides, steroids, and other classes. These antimicrobial metabolites will offer lead compounds to the development and innovation of antimicrobial agents.

Keywords: Aspergillus sp.; antibacterial activity; antimicrobial resistance; marine-derived; secondary metabolites.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer FC declared a past co-authorship with the author CZ to the handling editor.

Figures

Figure 1
Figure 1
Chemical structures of antibacterial sesquiterpenes 1–18 from Aspergillus spp.
Figure 2
Figure 2
Chemical structures of antibacterial diterpenoids 19–22 from Aspergillus spp.
Figure 3
Figure 3
Chemical structures of antibacterial meroterpenoids 23–32 from Aspergillus spp.
Figure 4
Figure 4
Chemical structures of antibacterial indole alkaloids 33–71 from Aspergillus spp.
Figure 5
Figure 5
Chemical structures of antibacterial quinazolinone alkaloids 72–82 from Aspergillus spp.
Figure 6
Figure 6
Chemical structures of antibacterial cytochalasan alkaloids 83–86 from Aspergillus spp.
Figure 7
Figure 7
Chemical structures of antibacterial cytochalasan alkaloids 87–99 from Aspergillus spp.
Figure 8
Figure 8
Chemical structures of other nitrogen-containing antibacterial metabolites 100–130 from Aspergillus spp.
Figure 9
Figure 9
Chemical structures of antibacterial anthraquinones 131–150 from Aspergillus spp.
Figure 10
Figure 10
Chemical structures of antibacterial xanthones 151–181 from Aspergillus spp.
Figure 11
Figure 11
Chemical structures of antibacterial lactones 182–240 from Aspergillus spp.
Figure 12
Figure 12
Chemical structures of other antibacterial polyketide metabolites 241–269 from Aspergillus spp.
Figure 13
Figure 13
Chemical structures of antibacterial steroids 270–287 from Aspergillus spp.
Figure 14
Figure 14
Chemical structures of other antibacterial classes 288–337 from Aspergillus spp.
Figure 15
Figure 15
Structural diversity of the antibacterial secondary metabolites from the genus of Aspergillus (January 2010 to June 2024).
Figure 16
Figure 16
The number and types of compounds with broad-spectrum antibacterial activity, activity against resistant bacteria, and activity against non-human pathogenic bacteria.
Figure 17
Figure 17
The proportion of Aspergillus from different marine sources.
Figure 18
Figure 18
Each year of the antibacterial secondary metabolites from the genus of Aspergillus (2010–2023) (the data for 2024 is not accurate, so it will not be included).
See this image and copyright information in PMC

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