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. 2024 Sep 26:2024:7344506.
doi: 10.1155/2024/7344506. eCollection 2024.

Assessment of COVID-19 Vaccine Impact on Women's Menstrual Health within an 18-Month Follow-Up

Mona Sadat Larijani  1 , Sana Eybpoosh  2 , Delaram Doroud  3 , Anahita Bavand  1 , Ladan Moradi  1 , Fatemeh Ashrafian  1 , Parinaz Tajmehrabi Namini  1 , Mahsan Zali  1 , Amitis Ramezani  1
Affiliations

Assessment of COVID-19 Vaccine Impact on Women's Menstrual Health within an 18-Month Follow-Up

Mona Sadat Larijani et al. Obstet Gynecol Int. .

Abstract

Considering menstruation as a crucial factor in females' health and fertility, any factor that could change its cycle is important. This study was conducted from April 2021 to October 2022 on females who got 3 doses of vaccines against SARS-CoV-2 through different platforms. The participants were requested to provide the trained experts with any changes regarding menstrual cycles after each dose of the vaccine up to 6 months after the booster shots. The disturbances related to the vaccines were identified by the adverse events committee to find possible associations with the applied vaccines. Of 308 women who participated until the end of the study, 22 (7.1%) complained about at least one abnormality in their menstrual patterns. The most common disturbance was metrorrhagia as 10 (48%) incidences followed by menorrhagia as 6 events (24.2%). Notably, the identified complaints were persistent in 59% of the patients. In addition, 14 studied cases developed COVID-19 infection after menstrual disorders. In these cases, COVID-19 could also play a role in the persistence of postvaccine menstrual disturbances. COVID-19 vaccination could affect menstrual cycle in women with no remarkable previous medical history. More longitudinal studies are required regarding this issue.

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Conflict of interest statement

The authors declare that they have no relevant financial or nonfinancial conflicts of interest.

Figures

Figure 1
Figure 1
The summary of the follow-up study. A total population of 308 females were followed after COVID-19 vaccination with different platforms. The menstrual disorders were classified according to the AEs Committee of Pasteur Institute of Iran. Standard vaccinations included two doses of PastoCovac and one dose of PastoCovac Plus, three doses of Sinopharm, and three doses of AstraZeneca; combinational vaccine regimens included two doses of Sinopharm and 1 dose of PastoCovac Plus, two doses of AstraZeneca and 1 dose of PastoCovac Plus, and two doses of COVAXIN and 1 dose of PastoCovac Plus.
Figure 2
Figure 2
Menstrual disorders after COVID-19 vaccination. The incidences of menstrual disorders considering each vaccine dose in 5 different types were screened through the follow-up. This chart presents the number of each abnormality regarding vaccine doses. Some incidences occurred after each dose while some were dose-limited.
Figure 3
Figure 3
Duration of menstrual disorders. 22 individuals complained about at least one MD, which was durable for at least 1 month. Most of the screened problems were persistent up to the end of the study.
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