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. 2024 Sep 3;16(9):e68531.
doi: 10.7759/cureus.68531. eCollection 2024 Sep.

The Predictive Role of Indices Indirectly Indicating Hyperlipidemia and Inflammation in Ascending Aortic Aneurysm

Hasan Sari  1 , Yunus E Yavuz  2 , Muhammed F Kaleli  3 , Serhat Kesriklioglu  3 , Yakup Alsancak  3
Affiliations

The Predictive Role of Indices Indirectly Indicating Hyperlipidemia and Inflammation in Ascending Aortic Aneurysm

Hasan Sari et al. Cureus. .

Abstract

Introduction Ascending aortic aneurysm (AAA) is an aortic disease that can progress with serious complications. The roles of hyperlipidemia and inflammation in its etiology are controversial. In this study, we aimed to investigate the predictive value of indices that can indirectly reflect hyperlipidemia and inflammation in patients with AAA. Methods This prospective study included 146 patients diagnosed with AAA and 88 controls. Demographic data, clinical history and laboratory results, including the atherogenic index of plasma (AIP), atherogenic coefficient (AC), pan-immune-inflammation value (PIV), and systemic immune-inflammation index (SII), were collected. Statistical analyses were performed to evaluate the relationships between these indices and the aortic diameter. Results Patients with AAA presented significantly higher PIV levels than controls did (p>0.05). However, no significant differences were observed in the AIP, AC, or SII between the patient and control groups. Furthermore, no significant correlation was found between the aortic diameter and the studied indices (p<0.05). PIV was the only significant parameter with a p-value of 0.026 (AUC: 0.587) according to the ROC analysis. Conclusion These findings suggest that while hyperlipidemia, as measured by the AIP and AC, may not play a direct role in AAA progression, inflammation indicated by PIV could be an important factor. Especially in resource-limited settings, these useful indicators can improve AAA management before the disease progresses to an advanced stage.

Keywords: ascending aortic aneurysm; atherogenic index of plasma; hyperlipidemia; inflammation; pan-immune-inflammation value; prognostic indicators.

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Conflict of interest statement

Human subjects: Consent was obtained or waived by all participants in this study. Necmettin Erbakan University's Ethics Committee issued approval 2022/3714 (01.04.2022). Our study titled "The Predictive Role of Indices Indirectly Indicating Hyperlipidemia and Inflammation in Ascending Aortic Aneurysm" was evaluated at the 151st meeting on April 1, 2024. Approval was received from the Necmettin Erbakan University Ethics Committee with the reference number 2022/3714. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. ROC curves for the calculated indices
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