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. 2024 Nov;60(10):6395-6407.
doi: 10.1111/ejn.16558. Epub 2024 Oct 4.

Psilocybin reduces functional correlation and the encoding of spatial information by neurons in mouse retrosplenial cortex

Victorita E Ivan  1 , David P Tomàs-Cuesta  1 , Ingrid M Esteves  1 , Artur Luczak  1 , Majid Mohajerani  1   2 , Bruce L McNaughton  1   3 , Aaron J Gruber  1
Affiliations

Psilocybin reduces functional correlation and the encoding of spatial information by neurons in mouse retrosplenial cortex

Victorita E Ivan et al. Eur J Neurosci. 2024 Nov.

Abstract

Psychedelic drugs have profound effects on perception, cognition and mood. How psychedelics affect neural signaling to produce these effects remains poorly understood. We investigated the effect of the classic psychedelic psilocybin on neural activity patterns and spatial encoding in the retrosplenial cortex of head-fixed mice navigating on a treadmill. The place specificity of neurons to distinct locations along the belt was reduced by psilocybin. Moreover, the stability of place-related activity across trials decreased. Psilocybin also reduced the functional correlation among simultaneously recorded neurons. The 5-HT2AR (serotonin 2A receptor) antagonist ketanserin blocked these effects. These data are consistent with proposals that psychedelics increase the entropy of neural signaling and provide a potential neural mechanism contributing to disorientation frequently reported by humans after taking psychedelics.

Keywords: ketanserin; mutual information; psychedelics; retrosplenial cortex; serotonin.

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References

REFERENCES

    1. Alexander, A. S., & Nitz, D. A. (2015). Retrosplenial cortex maps the conjunction of internal and external spaces. Nature Neuroscience, 18(8), 1143–1151. https://doi.org/10.1038/nn.4058
    1. Andrade, R. (2011). Serotonergic regulation of neuronal excitability in the prefrontal cortex. Neuropharmacology, 61(3), 382–386. https://doi.org/10.1016/j.neuropharm.2011.01.015
    1. Atasoy, S., Roseman, L., Kaelen, M., Kringelbach, M. L., Deco, G., & Carhart‐Harris, R. L. (2017). Connectome‐harmonic decomposition of human brain activity reveals dynamical repertoire re‐organization under LSD. Scientific Reports, 7(1), 17661. https://doi.org/10.1038/s41598-017-17546-0
    1. Berke, M. S., Fensholdt, L. K. D., Hestehave, S., Kalliokoski, O., & Abelson, K. S. P. (2022). Effects of buprenorphine on model development in an adjuvant‐induced monoarthritis rat model. PLoS ONE, 17(1), e0260356. https://doi.org/10.1371/journal.pone.0260356
    1. Carbonaro, T. M., Bradstreet, M. P., Barrett, F. S., MacLean, K. A., Jesse, R., Johnson, M. W., & Griffiths, R. R. (2016). Survey study of challenging experiences after ingesting psilocybin mushrooms: Acute and enduring positive and negative consequences. Journal of Psychopharmacology, 30(12), 1268–1278. https://doi.org/10.1177/0269881116662634

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