Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Dec;24(12):1428-1438.
doi: 10.1007/s12012-024-09923-9. Epub 2024 Oct 4.

Advances in Factors Affecting ALDH2 Activity and its Mechanisms

Yun Liu #  1   2   3   4 , Xuemei Liu #  5 , Chang Pan #  6   7   8   9
Affiliations
Review

Advances in Factors Affecting ALDH2 Activity and its Mechanisms

Yun Liu et al. Cardiovasc Toxicol. 2024 Dec.

Abstract

Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme primarily involved in the detoxification of alcohol-derived aldehyde and endogenous toxic aldehydes. It exhibits widespread expression across various organs and exerts a broad and significant impact on diverse acute cardiovascular diseases, including acute coronary syndrome, acute aortic dissection, hypoxic pulmonary hypertension, and heart failure. The ALDH2 rs671 variant represents the most prevalent genetic variant in East Asian populations, with carriage rates ranging from 30 to 50% among the Chinese population. Given its widespread presence in the body, the wide range of diseases it affects, and its high rate of variation, it can serve as a crucial tool for the precise prevention and treatment of acute cardiovascular diseases, while offering individualized medication guidance. This review aims to provide a comprehensive overview of the latest advancements in factors affecting ALDH2 activity, encompassing post-transcriptional modifications, modulators of ALDH2, and relevant clinical drugs.

Keywords: ALDH2; Cardiovascular disease; Enzymatic activity.

PubMed Disclaimer

Conflict of interest statement

Declarations Competing Interests The authors declare no competing interests.

Similar articles

See all similar articles

Cited by

References

    1. Matsumoto, A. (2016). Fundamental properties of aldehyde dehydrogenase 2 (ALDH2) and the importance of the ALDH2 polymorphism. Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene), 71(1), 55–68. - PubMed - DOI
    1. Guo, X., Disatnik, M. H., Monbureau, M., Shamloo, M., Mochly-Rosen, D., & Qi, X. (2013). Inhibition of mitochondrial fragmentation diminishes Huntington’s disease-associated neurodegeneration. Journal of Clinical Investigation, 123(12), 5371–5388. - PubMed - PMC - DOI
    1. Zhong, S., Li, L., Zhang, Y. L., Zhang, L., Lu, J., Guo, S., Liang, N., Ge, J., Zhu, M., Tao, Y., Wu, Y. C., & Yin, H. (2019). Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation. Journal of Clinical Investigation, 129(1), 252–267. - PubMed - DOI
    1. Zhang, H., & Fu, L. (2021). The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatment. Acta Pharmaceutica Sinica B, 11(6), 1400–1411. - PubMed - PMC - DOI
    1. Ebert, A. D., Kodo, K., Liang, P., Wu, H., Huber, B. C., Riegler, J., Churko, J., Lee, J., de Almeida, P., Lan, F., Diecke, S., Burridge, P. W., Gold, J. D., Mochly-Rosen, D., & Wu, J. C. (2014). Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase genetic polymorphism using a human induced pluripotent stem cell model system. Science Translational Medicine, 6, 255ra130. - PubMed - PMC - DOI

MeSH terms

Substances

LinkOut - more resources