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Review
. 2024 Dec;24(12):1410-1427.
doi: 10.1007/s12012-024-09926-6. Epub 2024 Oct 4.

The Multifaceted Roles of Hippo-YAP in Cardiovascular Diseases

Hao Wu  1 , Yan-Nan Che  2 , Qi Lan  1 , Yi-Xiang He  2 , Ping Liu  1 , Ming-Tai Chen  3 , Li Dong  4 , Meng-Nan Liu  5
Affiliations
Review

The Multifaceted Roles of Hippo-YAP in Cardiovascular Diseases

Hao Wu et al. Cardiovasc Toxicol. 2024 Dec.

Abstract

The Hippo-yes-associated protein (YAP) signaling pathway plays a crucial role in cell proliferation, differentiation, and death. It is known to have impact on the progression and development of cardiovascular diseases (CVDs) as well as in the regeneration of cardiomyocytes (CMs). However, further research is needed to understand the molecular mechanisms by which the Hippo-YAP pathway affects the pathological processes of CVDs in order to evaluate its potential clinical applications. In this review, we have summarized the recent findings on the role of the Hippo-YAP pathway in CVDs such as myocardial infarction, heart failure, and cardiomyopathy, as well as its in CM development. This review calls attention to the potential roles of the Hippo-YAP pathway as a relevant target for the future treatment of CVDs.

Keywords: Cardiac repair; Cardiomyocytes; Cardiovascular diseases; Hippo; Yes-associated protein.

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Conflict of interest statement

Declarations Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Ethical Approval Not applicable. Consent to Participate None. Consent for Publication All the authors have read and approved the final version of the manuscript and gave their consent for publication.

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