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. 2024 Oct 3;84(19):3576-3577.
doi: 10.1016/j.molcel.2024.09.014.

50 years in the making: acp3U, an amino-acid-containing nucleoside, links N-glycans and RNA in glycoRNA

Kfir B Steinbuch  1 , Yitzhak Tor  2
Affiliations

50 years in the making: acp3U, an amino-acid-containing nucleoside, links N-glycans and RNA in glycoRNA

Kfir B Steinbuch et al. Mol Cell. .

Abstract

In a recent publication in Cell, Xie et al.1 report a sensitive and scalable method for the detection and characterization of native glycoRNAs and identify acp3U, an abundant modified nucleoside discovered 50 years ago in tRNAPhe, as one of the primary attachment sites for N-glycans.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Figures

Figure 1.
Figure 1.. Deciphering the molecular structure of glycoRNA
Cartoon representation of a generic sialicglycoRNA (left). An amino-acid-containing nucleoside, acp3U, a verified N-glycan anchoring nucleoside, is shown next to other carboxylic-acid- and carboxamide-containing nucleosides, which may also serve as attachment sites for oligosaccharides (right).
See this image and copyright information in PMC

Comment on

References

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