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. 2024 Oct 3;84(19):3593-3595.
doi: 10.1016/j.molcel.2024.09.010.

PRC2-RNA interactions: Viewpoint from Tom Cech, Chen Davidovich, and Richard Jenner

Thomas R Cech  1 , Chen Davidovich  2 , Richard G Jenner  3
Affiliations
Free article

PRC2-RNA interactions: Viewpoint from Tom Cech, Chen Davidovich, and Richard Jenner

Thomas R Cech et al. Mol Cell. .
Free article

Abstract

Diverse biochemical, structural, and in vivo data support models for the regulation of polycomb repressive complex 2 (PRC2) activity by RNAs, which may contribute to the maintenance of epigenetic states. Here, we summarize this research and also suggest why it can be difficult to capture biologically relevant PRC2-RNA interactions in living cells.

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Conflict of interest statement

Declaration of interests T.R.C. is a scientific advisor for Storm Therapeutics, Eikon Therapeutics, lincSwitch Therapeutics, and SomaLogic.

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