[Current concepts of the functional characteristics of the muscarinic cholinoceptor]

Abstract

Methodical approaches to the investigation of M-cholinoreceptors of the CNS and peripheral organs are considered. The materials on heterogeneity of M-cholinoreceptors population and the ways of interconversion of their heterogeneous molecular forms are discussed. Special attention is given to the contribution of G-proteins to the functioning of M-cholinoreceptors and to the role of guanylic nucleotides in changes of their affinity to cholinergic ligands. Materials are presented on the participation of guanyl nucleotides--G-protein system in the realization of the functional interrelations of cholino- and adrenoreactive systems.