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Review
. 2024 Oct 4;24(1):285.
doi: 10.1186/s12893-024-02526-9.

Efficacy and safety of intraperitoneal chemotherapy for pancreatic cancer

Dorsa Safari  1 , Mohammad Fakhrolmobasheri  1 , Saeed Soleymanjahi  2
Affiliations
Review

Efficacy and safety of intraperitoneal chemotherapy for pancreatic cancer

Dorsa Safari et al. BMC Surg. .

Abstract

Pancreatic cancer is a highly aggressive cancer with unfavorable prognosis despite the therapeutic interventions. Intraperitoneal chemotherapy has recently shown potential outcomes in the presence of peritoneal metastases. However, a consensus is still lacking on different methods for intraperitoneal chemotherapy in pancreatic cancer. A variety of drugs and doses via three types of intraperitoneal chemotherapy have been studied. The prognosis and treatment strategies for pancreatic ductal adenocarcinoma (PDAC) will be significantly influenced by peritoneal dissemination and resectability of the macroscopic disease. Normothermic intraperitoneal chemotherapy (NIPEC) has been used for the treatment of peritoneal metastases of pancreatic carcinomas. Intraperitoneal chemotherapy is often combined with systemic therapies or surgical procedures which may lead to favorable combination therapies such as cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a relatively new approach that provides a homogenous and deep penetration of the chemotherapy into the peritoneum by producing aerosols. The present study aims to review the literature for recent evidence on intraperitoneal chemotherapy in pancreatic cancer.

Keywords: Cytoreductive surgery (CRS); Hyperthermic intraperitoneal chemotherapy (HIPEC); Intraperitoneal chemotherapy (IP chemotherapy); Pancreatic cancer; Peritoneal metastasis; Pressurized intraperitoneal aerosol chemotherapy (PIPAC).

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
HIPEC using a CO2 recirculation system. HIPEC, Hyperthermic intraperitoneal chemotherapy
See this image and copyright information in PMC

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