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. 2025 Feb;31(2):532-540.
doi: 10.1111/odi.15146. Epub 2024 Oct 6.

Epidemiological Features of 4777 Cysts and Odontogenic Tumors Based on the 2022 WHO Classification

Victoria Rees  1 , Matías Klare  1 , Valentina Samaniego  2 , Felipe Leiva  2 , René Jara  1 , Benjamín Martínez Rondanelli  1 , Sergio González Providell  1   3
Affiliations

Epidemiological Features of 4777 Cysts and Odontogenic Tumors Based on the 2022 WHO Classification

Victoria Rees et al. Oral Dis. 2025 Feb.

Abstract

Objective: The epidemiology of cysts and odontogenic tumors is important for differential diagnosis and treatment strategies. We aimed to describe the epidemiological features of cysts and odontogenic tumors in the Chilean population using the current WHO classification.

Materials and methods: We reviewed 22,914 biopsy requests received between January 1984 and September 2023 at the oral pathology department, School of Dentistry, Universidad Mayor, Santiago, Chile. Patients diagnosed with cysts of the jaws and odontogenic tumors were selected and information regarding age, sex, and location was recorded.

Results: 4226 (18.4%) were cysts, and 551 (2.4%) were odontogenic tumors, ranging from 2 to 97 years old. Males represented 54.4% and females 45.7% of the total sample. The most prevalent cysts were radicular cysts (58.6%), dentigerous cysts (17.9%), and odontogenic keratocysts (13.3%). The most prevalent odontogenic tumors were odontomas (40.1%) and conventional ameloblastoma (17.6%).

Conclusions: Our study was the first retrospective analysis to determine the epidemiological features of both cysts and odontogenic tumors together, based on the 2022 WHO classification. This is relevant as it offers a potential basis for comprehensive comparisons of the epidemiological features of these entities, which could contribute to an accurate differential diagnosis, therefore, leading to more effective therapeutic interventions.

Keywords: WHO classification; cysts of the jaws; differential diagnosis; odontogenic tumors.

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