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. 2024 Oct;14(10):e70008.
doi: 10.1002/ctm2.70008.

Harnessing apoptotic cells to enhance efficiency of macrophage-based cell therapy

Imke Liebold  1   2 , Lidia Bosurgi  1   2
Affiliations

Harnessing apoptotic cells to enhance efficiency of macrophage-based cell therapy

Imke Liebold et al. Clin Transl Med. 2024 Oct.
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Feeding macrophages with apoptotic neutrophils increases the efficiency of macrophage‐based cell therapies in Schistosoma mansoni infection. Macrophages fed with apoptotic neutrophils (aN), apoptotic thymocytes (aT), or apoptotic hepatocytes (aH) and then stimulated with interleukin (IL)‐4, acquire in vitro distinct transcriptomic profiles depending on the type of apoptotic cell engulfed. Expression of genes like Chil3 and Rentla is potentiated only when IL‐4‐activated macrophages engulf aN, Socs2 and Cd274 are induced upon uptake of aH, and Serpinb9b and Cd274 upon phagocytosis of aH. Uptake of aN is mediated by the engagement of the receptor tyrosine kinases AXL and MERTK. In vivo, only the adoptive transfer of aN‐fed macrophages, but not aT or aH‐fed macrophages, reduces parasitic egg load in the colon of S. mansoni‐infected mice.
See this image and copyright information in PMC

References

    1. Barkal AA, Brewer RE, Markovic M, et al. CD24 signalling through macrophage Siglec‐10 is a target for cancer immunotherapy. Nature. 2019;572(7769):392‐396. doi:10.1038/s41586-019-1456-0 - DOI - PMC - PubMed
    1. Gordon SR, Maute RL, Dulken BW, et al. PD‐1 expression by tumour‐associated macrophages inhibits phagocytosis and tumour immunity. Nature. 2017;545(7655):495‐499. doi:10.1038/nature22396 - DOI - PMC - PubMed
    1. Voll RE, Herrmann M, Roth EA, Stach C, Kalden JR, Girkontaite I. Immunosuppressive effects of apoptotic cells. Nature. 1997;390(6658):350‐351. doi:10.1038/37022 - DOI - PubMed
    1. Fadok VA, Bratton DL, Konowal A, et al. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF‐beta, PGE2, and PAF. J Clin Invest. 1998;101(4):890‐898. doi:10.1172/JCI1112 - DOI - PMC - PubMed
    1. Bosurgi L, Cao YG, Cabeza‐Cabrerizo M, et al. Macrophage function in tissue repair and remodeling requires IL‐4 or IL‐13 with apoptotic cells. Science. 2017;356(6342):1072‐1076. doi:10.1126/science.aai8132 - DOI - PMC - PubMed

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