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Case Reports
. 2024 Sep 4;16(9):e68674.
doi: 10.7759/cureus.68674. eCollection 2024 Sep.

Solitary Giant Primary Gastric Plasmacytoma Mimicking Gastric Adenocarcinoma In Situ

Sergio A Bolivar  1 , Patricia Medina  2 , Maria Cynthia Fuentes  2 , Humberto Martinez-Cordero  2 , German Salguedo  3
Affiliations
Case Reports

Solitary Giant Primary Gastric Plasmacytoma Mimicking Gastric Adenocarcinoma In Situ

Sergio A Bolivar et al. Cureus. .

Abstract

A solitary extraosseous plasmacytoma is a rare type of plasma cell neoplasm. Its occurrence in the stomach is particularly unusual and can easily be mistaken for more common types of tumors. We describe a case involving a solitary extraosseous plasmacytoma in a patient who experienced weight loss as the sole symptom. Initially, the condition was misdiagnosed as gastric adenocarcinoma based on endoscopic biopsy results, leading to a gastrectomy after neoadjuvant chemotherapy. Subsequent examination of the pathological specimen revealed the presence of plasma cell neoplasia alongside a gastric adenocarcinoma in situ.

Keywords: adenocarcinoma; hemato-oncology; immunohistochemistry; plasma cell neoplasms; primary gastric plasmacytoma.

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Conflict of interest statement

Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Contrast-enhanced abdominal computed tomography (CT)
A mass can be observed in the posteromedial wall of the gastric fundus, multilobulated and enhanced with contrast medium, reaching dimensions of 42 × 52 × 60 mm, indicated by the orange arrow.
Figure 2
Figure 2. Morphological and immunohistochemical analysis of the tumor lesion
Histologic sections show a gastric wall with a diffuse infiltrate of neoplastic cells below the muscularis mucosae (stars) (A). Neoplastic cells have plasmacytic morphology with eccentric nuclei and abundant amphophilic cytoplasm (black arrows) (B). Immunohistochemistry reveals strong expression of CD38 confirming plasmacytic lineage (C), with monotypic expression of kappa light chain (D), without expression of lambda light chain (E).
See this image and copyright information in PMC

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