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Review
. 2025 Nov;93(5):1213-1224.
doi: 10.1016/j.jaad.2024.09.049. Epub 2024 Oct 5.

Hand eczema-Part 2: Prevention, management, and treatment

Robert Bissonnette  1 , Tove Agner  2 , James S Taylor  3 , Sonja Molin  4 , Emma Guttman-Yassky  5
Affiliations
Review

Hand eczema-Part 2: Prevention, management, and treatment

Robert Bissonnette et al. J Am Acad Dermatol. 2025 Nov.

Abstract

Prevention methods are important for patients with hand eczema (HE), especially those with risk factors. Frequent use of moisturizers is encouraged. Few drugs have been approved specifically for HE. Topical corticosteroids remain the mainstay treatment. Several new topical and systemic drugs are currently in development for HE. Dupilumab has recently been shown effective for chronic HE. Established criteria can be used to help determine causality for occupational HE, which is important for worker's compensation. The second article of this CME series discusses prevention, management, treatment, and worker's compensation for HE.

Keywords: dermatitis; eczema; hand; hand dermatitis; hand eczema.

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Conflict of interest statement

Conflicts of interest Dr Bissonnette is an advisory board member, consultant, speaker, and/or investigator for and receives honoraria and/or grants from AbbVie, Arcutis, Arena Pharma, Asana BioSciences, Bellus Health, Bluefin Biomedicine, BioMimetix, Boehringer-Ingelheim, Boston, Brickell, CARA Therapeutic, Clexio, Dermavant, Eli Lilly, EMD Serono, Evidera, Galderma, GlaxoSmithKline, Incyte, Inmagene Bio, Janssen, Kiniksa, Kyowa Kirin, LEO Pharma, Novan, Novartis, Pfizer, Ralexar, RAPT Therapeutic, Regeneron, Respivant, Sanofi, Sienna, Target RWE, and Vyne Therapeutics; and is also an employee and shareholder of Innovaderm Research. Dr Agner has received honoraria as advisory board member, consultant, speaker, and/or investigator for Abbvie, Almirall, LEO Pharma, Eli-Lilly, Pfizer, Novartis, and Sanofi. Dr Taylor owns non-controlling common shares of stock in AstraZeneca, Cigna, Merck, Johnson & Johnson, and Opko Health. He has consulted for Kao Brands and Monsanto (Bayer), is a member of the Cosmetic Ingredient Review Steering Committee, and a non-dependent child is employed by Pfizer. Dr Molin has received honoraria as consultant/advisor or speaker and/or grants from Abbvie, Almirall, Aralez, Arcutis, Basilea, Bausch and Lomb, Bristol Myers Squibb, Boehringer-Ingelheim, Evidera, Galderma, GSK, Incyte, LEO Pharma, Lilly, Novartis, Pfizer, Sanofi, Sun Pharma, and UCB. She is currently an investigator for Novartis and LEO Pharma. Dr Guttman-Yassky is an employee of Mount Sinai and has received research grants from Boehringer Ingelheim, Leo Pharma, Pfizer, Cara Therapeutics, UCB, Kyowa Kirin, RAPT, Amgen, GSK, Incyte, Sanofi, Bristol Myers Squibb, Aslan, Regeneron, Anaptysbio, Concert, Janssen, and is a consultant for Abbvie, Almirall, Amgen, AnaptysBio, Apogee Therapeutics, Apollo Therapeutics Limited, Artax Biopharma Inc, AstraZeneca, Bristol Myers Squibb, Boerhinger-Ingelhiem, Cara Therapeutics, Centrexion Therapeutics Corporation, Connect Biopharm, Eli Lilly, Enveda Biosciences, Escient Pharmaceuticals, Inc, Fairmount Funds Management LLC, Forest Laboratories Galderma, Gate Bio, Google Ventures (GV), GSK Immunology, Horizon Therapeutics USA, Inc, Incyte, Inmagene, Janssen Biotech, JT Central Pharmaceutical Research Institute, Jasper Therapeutics, Kyowa Kirin, Leo Pharma, Merck, Nektar Therapeutics, Novartis Pharmaceuticals Corporation, NUMAB Therapeutics AG, OrbiMed Advisors LLC, OTSUKA, Pfizer, Pharmaxis Ltd, Pioneering Medicine VII, Inc, Proteologix US Inc, RAPT, Regeneron Pharmaceuticals, RibonTherapeutics, Inc, Sanofi, SATO, Schrödinger, Inc, Sun Pharma Advanced Research Company (SPARC), Teva Branded Pharmaceutical Products R&D, and UCB.

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