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Randomized Controlled Trial
. 2024 Nov;17(11):2430-2446.
doi: 10.1002/aur.3240. Epub 2024 Oct 7.

Comparative effectiveness trial: Modular behavior approach for young autistic children compared to comprehensive behavioral intervention

Cynthia Anderson  1 , Samantha Hochheimer  2 , Zachary Warren  3 , Eric Butter  4 , Susan L Hyman  2 , Hongyue Wang  2 , Lisa Wallace  3 , Lynne Levato  2 , Ryan Martin  1 , Kevin G Stephenson  4 , Megan Norris  4 , Wynn Jacqueline  4 , Tristram Smith  2 , Cynthia R Johnson  5
Affiliations
Randomized Controlled Trial

Comparative effectiveness trial: Modular behavior approach for young autistic children compared to comprehensive behavioral intervention

Cynthia Anderson et al. Autism Res. 2024 Nov.

Abstract

This 24-week single-blind trial tested a modular approach for young autistic children (MAYAC) that was delivered for fewer hours per week and modified based on child progress and parental input compared to comprehensive behavioral intervention treatment as usual (CBI, TAU). Participants were autistic children, ages 18-60 months of age. MAYAC was initially 5 h of intervention per week, one of which was parent training and the other four direct therapy focusing on social communication and engagement, but additional modules could be added for up to 10 h per week. Comprehensive behavior intervention was delivered for ≥15 h per week. Outcome measures included the Vineland Adaptive Behavior Scales; VABS, the Ohio Autism Clinical Improvement Scale - Autism Severity; OACIS - AS and the Pervasive Developmental Disorder Behavior Inventory - Parent; PDDBI-P. Implementation and parent satisfaction measures were also collected. Fifty-six children, mean age of 34 months, were randomized. Within-group analysis revealed significant improvements from baseline to week 24 for both MAYAC (p < 0.0001) and CBI, TAU (p < 0.0001) on the VABS. The noninferiority test was performed to test between group differences and MAYAC was not inferior to CBI, TAU on the VABS (p = 0.0144). On the OACIS - AS, 48.0% of MAYAC and 45.5% of CBI were treatment responders there were no significant changes on the PDDBI-P, for either group. Treatment fidelity was high for both groups (>95%) as was parent satisfaction. Findings from this small trial are promising and suggest MAYAC may be an alternative for some young autistic children and their families to CBI, TAU.

Keywords: applied behavior analysis; autism; behavioral intervention; comprehensive behavior intervention (CBI); discrete trial training (DTT); early intensive Behavioral intervention (EIBI); naturalistic developmental Behavioral interventions (NDBIs); noninferiority design; randomized clinical trial (RCT).

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References

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