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. 2024 Oct 9;16(10):evae216.
doi: 10.1093/gbe/evae216.

The Effect of the Presence and Absence of DNA Repair Genes on the Rate and Pattern of Mutation in Bacteria

Georgios Kalogiannis  1 , Adam Eyre-Walker  1
Affiliations

The Effect of the Presence and Absence of DNA Repair Genes on the Rate and Pattern of Mutation in Bacteria

Georgios Kalogiannis et al. Genome Biol Evol. .

Abstract

Bacteria lose and gain repair genes as they evolve. Here, we investigate the consequences of gain and loss of 11 DNA repair genes across a broad range of bacteria. Using synonymous polymorphisms from bacteria and a set of 50 phylogenetically independent contrasts, we find no evidence that the presence or absence of these 11 genes affects either the overall level of diversity or the pattern of mutation. Using phylogenetic generalized linear squares yields a similar conclusion. It seems likely that the lack of an effect is due to variation in the genetic background and the environment which obscures any effects that the presence or absence of individual genes might have.

Keywords: DNA repair; bacteria; mutation pattern.

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Figures

Fig. 1.
Fig. 1.
The phylogeny of the 290 species used in this analysis along with the presence and absence of 11 DNA repair genes coded as turquoise (presence) and red (absence).
See this image and copyright information in PMC

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