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. 2024 Oct;76(5):3807-3814.
doi: 10.1007/s12070-024-04636-5. Epub 2024 May 9.

Differentiated Thyroid Cancers with Synchronous Second Primary Cancers: Case Series

Devarajan Jebin Aaron  1   2 , Priyank Rathod  1   3 , Shailee Mehta  1   4 , Ajinkya Pawar  1   2 , Imran Nasir  1   2 , Anish Chowdhury  1   2 , Kanika Kapur  1   2 , Mohit Sharma  1   2 , Ketul Puj  1   2 , Vikas Warikoo  1   2 , Shailesh Patel  1   2 , Keval Patel  1   2 , Abhijeet Salunke  1   2 , Priti Trivedi  1   4 , Vivek Bande  1   2 , Salahudheen Thottiyen  1   2 , Sonal Trivedi  1   2 , Nikunj Patel  1   2 , Gautami Joshi  1   2 , Shashank Pandya  1   2
Affiliations

Differentiated Thyroid Cancers with Synchronous Second Primary Cancers: Case Series

Devarajan Jebin Aaron et al. Indian J Otolaryngol Head Neck Surg. 2024 Oct.

Abstract

The incidence of synchronous second primary cancer (SSPC) with DIfferentiated Thyroid Cancers (DTC) is a very rare entity. Very few case reports and case series were published in the literature. To enumerate the clinicopathological data of patients with DTC with SSPC. This is a single-center retrospective study. All the patients diagnosed with DTC and SSPC from January 2016 to July 2023 were included in the study. The demographic, clinicopathological data, and survival data were collected from the institute's database. Twelve patients were found to have DTC with SSPC. All the patients had papillary thyroid cancer. Ten patients had head and neck squamous cell carcinoma, one patient had malignant phyllodes tumor, and another patient had endometrioid adenocarcinoma as the SSPC. Six patients were diagnosed during preoperative evaluation, one patient was diagnosed 3 months after the oral malignancy diagnosis, and five patients were diagnosed with PTC in cervical nodes after neck dissection. Complete thyroid removal was done in six patients and hemithyroidectomy in two patients. The median follow-up was 25.55 months. The median overall survival was 40.97 months. Head and neck SCC is the most common SSPC with DTC. Since these are rare scenarios multi-disciplinary panel discussion can help in deciding management.

Keywords: Differentiated thyroid cancers; Papillary thyroid carcinoma; Synchronous oral primary cancers; Synchronous second primary cancers.

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Conflict of interest statement

Conflict of interestsNo conflicts of interest for any of the authors.

Figures

Fig. 1
Fig. 1
surgical management of thyroid cancer in the study group
Fig. 2
Fig. 2
Patient presented with synchronous malignant phyllodes tumor and Papillary thyroid carcinoma. a papillary thyroid
Fig. 3
Fig. 3
Patient presented with carcinoma tongue with Papillary thyroid carcinoma in lymph nodes. a, b squamous cell carcinoma
Fig. 4
Fig. 4
Patient presented with Ovarian endometroid carcinoma and papillary thyroid carcinoma. a, b representative
See this image and copyright information in PMC

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