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Review
. 2024 Sep 6;16(9):e68807.
doi: 10.7759/cureus.68807. eCollection 2024 Sep.

The Science of Solid Lipid Nanoparticles: From Fundamentals to Applications

Navaneetha Krishnan M  1 , Sangeetha S  1 , Sree Ranjani P  1 , Damodharan Narayanasamy  1
Affiliations
Review

The Science of Solid Lipid Nanoparticles: From Fundamentals to Applications

Navaneetha Krishnan M et al. Cureus. .

Abstract

Solid lipid nanoparticles (SLNs) play a crucial role in drug delivery, offering benefits such as enhanced bioavailability, targeted distribution, and reduced toxicity. This article provides a comprehensive overview of SLN formulation, development, and advancement in pharmaceutical research, examining their characteristics, classifications, and significance. The review also delves into the real-world applicability of various SLN formulations across different routes of administration, discussing their advantages, disadvantages, and challenges of scalability, along with strategies for efficient implementation. Furthermore, it explores the diverse applications of SLNs through various delivery methods, addressing the obstacles and potential solutions. By highlighting the critical role of SLNs in improving treatment outcomes, this review underscores their importance in modern drug delivery systems.

Keywords: applications of slns; drug delivery; drug delivery system; nanocarriers; nanostructured lipid carriers; solid lipid nanoparticles (slns).

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Conflict of interest statement

Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Solid lipid nanoparticles
Image credit: Dr. Navaneetha Krishnan M
Figure 2
Figure 2. Hot homogenization
Image credit: Dr. Navaneetha Krishnan M SLNs: Solid lipid nanoparticles
Figure 3
Figure 3. Cold homogenization
Image credit: Dr. Navaneetha Krishnan M SLNs: Solid lipid nanoparticles
Figure 4
Figure 4. Solvent injection method
Image credit: Navaneetha Krishnan M SLNs: Solid lipid nanoparticles
Figure 5
Figure 5. Micro emulsion
Image credit: Navaneetha Krishnan M SLNs: Solid lipid nanoparticles
See this image and copyright information in PMC

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