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Review
. 2024 Sep 23:14:1469178.
doi: 10.3389/fonc.2024.1469178. eCollection 2024.

Ferroptosis: a new mechanism of traditional Chinese medicine for treating hematologic malignancies

Xinyue Gou  1 , Xudong Tang  2 , Chi Liu  2 , Zhuo Chen  2
Affiliations
Review

Ferroptosis: a new mechanism of traditional Chinese medicine for treating hematologic malignancies

Xinyue Gou et al. Front Oncol. .

Abstract

Ferroptosis is a recently identified form of cell death characterized by lipid peroxidation and elevated iron levels. It is closely associated with hematologic malignancies, including leukemia, multiple myeloma (MM), and myelodysplastic syndromes (MDS). Research indicates that ferroptosis could represent a novel therapeutic target for these hematologic malignancies. Furthermore, traditional Chinese medicine (TCM) has been shown to modulate hematologic malignancies through the ferroptosis pathway. This paper aims to elucidate the mechanisms underlying ferroptosis and summarize the current research advancements regarding ferroptosis in hematologic malignancies, as well as the role of traditional Chinese medicine in the prevention and treatment of ferroptosis, with the goal of enhancing treatment efficacy.

Keywords: Chinese medicine; ferroptosis; hematologic malignancies; leukemia; myelodysplastic syndromes.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
(A) Mechanisms of ferroptosis (by Figdraw). ROS, reactive oxygen species; GPX4, glutathione peroxidase 4; GSH, glutathione; PUFA, Polyunsaturated Fatty Acids; LPCAT3, lysophospholipid acyltransferase 3; ACSL4, long-chain esteroyl coenzyme A synthetase 4; TFR, Transferrin Receptor; LOX, lipoxygenase. (B) The mechanism of traditional Chinese medicine compounds in ferroptosis (by Figdraw); DHA, dihydroartemisinin; STAT3, Signal Transducer and Activator of Transcription 3.
See this image and copyright information in PMC

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References

    1. Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, et al. . Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. (2012) 149(5):1060–72. doi: 10.1016/j.cell.2012.03.042 - DOI - PMC - PubMed
    1. Chen Z, Jiang J, Fu N, Chen L. Targetting ferroptosis for blood cell-related diseases. J Drug Target. (2022) 30(3):244–58. doi: 10.1080/1061186X.2021.1971237 - DOI - PubMed
    1. Yagoda N, von Rechenberg M, Zaganjor E, Bauer AJ, Yang WS, Fridman DJ, et al. . RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature. (2007) 447(7146):864–8. doi: 10.1038/nature05859 - DOI - PMC - PubMed
    1. Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, et al. . Regulation of ferroptotic cancer cell death by GPX4. Cell. (2014) 156(1–2):317–31. doi: 10.1016/j.cell.2013.12.010 - DOI - PMC - PubMed
    1. Mou Y, Wang J, Wu J, He D, Zhang C, Duan C, et al. . Ferroptosis, a new form of cell death: opportunities and challenges in cancer. J Hematol Oncol. (2019) 12(1):34. doi: 10.1186/s13045-019-0720-y - DOI - PMC - PubMed

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