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. 2024 Oct 6;7(10):e70019.
doi: 10.1002/hsr2.70019. eCollection 2024 Oct.

Effects of zinc supplementation on sleep quality in humans: A systematic review of randomized controlled trials

Mostafa Shahraki Jazinaki  1 , Alireza Gheflati  1   2 , Mohammad Reza Shadmand Foumani Moghadam  2 , Saeid Hadi  3 , Maryam Razavidarmian  2 , Masoud Yaghob Nezhad  2 , Hale Akhtari  2 , Mona Nematizadeh  2 , Mohammad Safarian  1
Affiliations

Effects of zinc supplementation on sleep quality in humans: A systematic review of randomized controlled trials

Mostafa Shahraki Jazinaki et al. Health Sci Rep. .

Abstract

Background and aims: Alternative therapies, such as zinc supplementation, have been explored as potential interventions for sleep disorders. However, the efficacy of zinc supplementation in improving sleep quality remains uncertain. This systematic review aims to examine the impacts of zinc supplementation on sleep quality in humans.

Methods: The Web of Science, Medline, Scopus, and Google Scholar databases were comprehensively searched to find studies investigating the effect of zinc supplementation on sleep quality. After identifying relevant studies by screening, relevant data were extracted from them. The quality assessment was conducted using the Cochrane quality assessment tool.

Results: This systematic review included eight studies. The interventions ranged from 4 to 48 weeks, with a daily dose of zinc supplementation varying between 10 and 73.3 mg. The majority of the evidence examined in this review pointed to the significant improvement effect of zinc supplementation on sleep quality in adults compared to the control groups. Furthermore, zinc supplementation did not have a significant effect on sleep disorders. However, there was no consensus about these findings. Also, the effect of supplementation on sleep duration in nonadults was contradictory.

Conclusions: This systematic review suggests that zinc supplementation may lead to improvements in sleep quality. However, more research, primarily clinical trials, is needed to clarify the beneficial effects of zinc supplementation on sleep quality with consideration of dietary zinc intake and the Recommended Dietary Allowances of zinc (RDA) in the different populations. It is also recommended to investigate the effect of zinc supplementation on sleep quality in people with zinc deficiency in future studies.

Keywords: sleep quality; systematic reviews as topic; zinc.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of study selection for inclusion trials in the systematic review.
See this image and copyright information in PMC

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