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Review
. 2025 Mar;20(2):349-355.
doi: 10.1007/s11739-024-03790-6. Epub 2024 Oct 8.

Paraneoplastic systemic lupus erythematosus associated with dysgerminoma: a case report and literature review

Ran Ben David  1   2 , Mahmoud Abu-Shakra  3   4 , Mihai Meirovitz  5 , Tsafnat Test  6   7 , Nikita Medvedev  6   8 , Iftach Sagy  3   4
Affiliations
Review

Paraneoplastic systemic lupus erythematosus associated with dysgerminoma: a case report and literature review

Ran Ben David et al. Intern Emerg Med. 2025 Mar.

Abstract

Rheumatic paraneoplastic syndromes are rare and generally occur no longer than two years before diagnosis of the associated malignancy. Therefore, it can be an essential clue to occult malignancy. A healthy 18-year-old female with no underlying diseases was referred to the rheumatology clinic due to morning stiffness in her hands and a new rash on her fingers. Her labs showed a positive ANA, anti-double strand DNA antibody, anti-RNP, and anti-ribosomal P. Nine months after the diagnosis with SLE, the patient presented with elevated levels of lactate dehydrogenase. A total-body computed tomography scan revealed a solid mass in the pelvis. The pathological findings corresponded to a dysgerminoma tumor. Following surgical tumor removal and chemotherapy, the patient went into remission with both SLE and her oncology conditions, with no relapse of her lupus symptoms in a one-year follow-up. This case underscores the importance of considering malignancy in unexplained lupus symptoms, a crucial point for all physicians to be aware of. We identified 13 cases of paraneoplastic SLE in a literature review. In most cases, SLE is resolved after the tumor has been treated.

Keywords: Dysgerminoma; Paraneoplastic; Systemic lupus erythematosus.

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Conflict of interest statement

Declarations. Conflict of interest: The author(s) declare that they have no conflict of interest. Informed consent: Written informed consent for publication of clinical details and clinical images was obtained from the patient. Ethical approval: This article does not contain any studies with human participants performed by any of the authors. Data availability statement: The data that support the findings of this study are available on request from the corresponding author.

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