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. 2024 Oct 8;9(1):278.
doi: 10.1038/s41392-024-01997-9.

Beyond borders: the choroid plexus-immune communication during neuroinflammation

Anaelle Aurelie Dumas  1 , Adrià Dalmau Gasull  2 , Marco Prinz  3   4
Affiliations

Beyond borders: the choroid plexus-immune communication during neuroinflammation

Anaelle Aurelie Dumas et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Mechanism of ChP immune response to LPS infection. a Immune landscape of ChP under homoeostasis depicting the ChP macrophage populations, which reside in the stromal region and on the apical CSF-containing surface of the epithelial wall. b Acute immune response phase to intracerebroventricular delivery of LPS. Retnlg+ neutrophils and Ccr2+ Plac8+ monocytes enter the ChP via the blood stream into the stroma and through the epithelial barrier into the CSF tissue. Chil1+ Icam1+ inflamed epithelial cells, present during acute inflammation, coordinate immune recruitment and activation in the ChP via the expression of metalloproteases, chemokines and adhesion molecules. c By 72 h after LPS treatment, epiplexus macrophages support the resolution of inflammation by phagocytosing immune infiltrates and epithelial cell debris as well as secreting occludin, which contributes to epithelial barrier repair
See this image and copyright information in PMC

References

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