LRRK2 is not required for lysozyme expression in Paneth cells

Affiliations

¹ Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
² Amphista Therapeutics, Cambridge, UK.
³ Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Ninewells Hospital, Dundee, UK.
⁴ Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK. m.swamy@dundee.ac.uk.

Anna Tasegian et al. Nat Immunol. 2024 Nov.

. 2024 Nov;25(11):2037-2039.

doi: 10.1038/s41590-024-01972-0. Epub 2024 Oct 8.

¹ Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK.
² Amphista Therapeutics, Cambridge, UK.
³ Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Ninewells Hospital, Dundee, UK.
⁴ Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK. m.swamy@dundee.ac.uk.

No abstract available

References

1. Russo, I., Bubacco, L. & Greggio, E. LRRK2 as a target for modulating immune system responses. Neurobiol. Dis. 169, 105724 (2022). - DOI - PubMed
1. Wehkamp, J. & Stange, E. F. An update review on the Paneth cell as key to ileal Crohn’s disease. Front. Immunol. 11, 646 (2020). - DOI - PubMed
1. Zhang, Q. et al. Commensal bacteria direct selective cargo sorting to promote symbiosis. Nat. Immunol. 16, 918–926 (2015). - DOI - PubMed
1. Yin, X. et al. Niche-independent high-purity cultures of Lgr5⁺ intestinal stem cells and their progeny. Nat. Methods 11, 106–112 (2014). - DOI - PubMed
1. Gardet, A. et al. LRRK2 is involved in the IFN-γ response and host response to pathogens. J. Immunol. 185, 5577–5585 (2010). - DOI - PubMed