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Meta-Analysis
. 2024 Oct;44(5):859-870.
doi: 10.19852/j.cnki.jtcm.20240828.008.

Systematic review and Meta-analysis of brain plasticity associated with electroacupuncture in experimental ischemic stroke

X U Yingshan  1 , W U Chunxiao  2 , Y U Wei  3 , Guo Hongji  4 , L U Liming  4 , X U Nenggui  4 , Tang Chunzhi  4
Affiliations
Meta-Analysis

Systematic review and Meta-analysis of brain plasticity associated with electroacupuncture in experimental ischemic stroke

X U Yingshan et al. J Tradit Chin Med. 2024 Oct.

Abstract

Objective: To systematically evaluate the role of electroacupuncture in maintaining brain plasticity in ischemic stroke mediated brain damage.

Methods: We searched for all relevant trials published through Oct 7, 2022 from seven databases. Metho-dological quality was assessed using the CAMARADES Risk of Bias Tool. A Meta-analysis of comparative effects was performed using Review Manager v.5.3 software.

Results: A total of 101 studies involving 2148 animals were included. For most studies, primary outcomes results of the Meta-analysis indicate that EA significantly improved ischemic stroke rat's postsynaptic density thickness [Standardized Mean Difference (SMD) = 1.41, 95% confidence interval (CI) (0.59, 2.23), P = 0.0008], numerical density of synapses [SMD = 1.55, 95% CI (0.48, 2.63), P = 0.005] compared with non-EA-treated. Similarly, EA could improve parts of biomarkers of synapses, neurogenesis, angiogenesis and neurotrophin activity than the control group (P < 0.05).

Conclusion: The existing evidence suggests EA regulating ischemic stroke may be through brain plasticity. More rigorous and high quality studies should be conducted in the future.

Keywords: Meta-analysis; animal; brain plasticity; electroacupuncture; experimental ischemic stroke; systematic review.

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Figures

Figure 1
Figure 1. Study flow diagram: a PRISMA flow diagram of the study
PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses; CNKI: China National Knowledge Infrastructure Database; CBM: Chinese Biomedical Literature Database; VIP: China Science and Technology Journal Database.
Figure 2
Figure 2. Forest polot of the effects of EA on synaptic structure
A: forest plot of the effects of EA on PSD thickness; B: forest plot of the effects of EA on Nv; PSD: postsynaptic density; Nv: synaptic numerical density; EA: electroacupuncture; CI: confidence interval; IV: inverse variance; SD: standard deviation.
See this image and copyright information in PMC

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