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. 2024;19(17):1489-1496.
doi: 10.1080/17460913.2024.2406654. Epub 2024 Oct 9.

Soluble TREM-1 is not a useful biomarker in the diagnosis of early-onset neonatal sepsis

Tugce Nur Cayir Koc  1 , Dilek Kahvecioglu  2 , Aslihan Kose Cetinkaya  2 , Ahmet Oktem  2 , Melda Tas  2 , Hacer Dogan  3 , Mehmet Senes  3
Affiliations

Soluble TREM-1 is not a useful biomarker in the diagnosis of early-onset neonatal sepsis

Tugce Nur Cayir Koc et al. Future Microbiol. 2024.

Abstract

Aim: Sepsis remains a significant cause of morbidity and mortality in neonates. We aimed to investigate the use and reliability of the soluble triggering receptor expressed on myeloid cells (sTREM-1) biomarker for suspected early onset of neonatal sepsis (EONS).Materials & methods: 52 patients with suspected EONS and 30 healthy newborns were analyzed for sTREM-1 and other biomarkers.Results: It revealed that elevated levels of C-reactive protein (CRP), neutrophil (%), red cell distribution width (RDW), neutrophil/lymphocyte ratio (NLR) and lactate, as well as decreased lymphocyte (%) were statistically significant for EONS. However, there was no statistically significant difference in sTREM-1 levels between the groups.Conclusion: Although no significant difference in sTREM-1 levels was found between the groups, further research involving repeated measurements and larger sample sizes is necessary to evaluate its practical utility in clinical settings.

Keywords: biomarker; early neonatal sepsis; neonate; prematurity; sTREM-1.

Plain language summary

[Box: see text].

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Conflict of interest statement

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

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